chemical

Tetrabenazine

2175/10

10 mg (also 50 mg)

220 USD

2175

2175/10

Tetrabenazine

Potent inhibitor of vesicular monoamine transport

Vesicular Monoamine Transporter Inhibitors

10 mg (also 50 mg)

Small Molecules

98%

Store at +4°C

317.2

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Tetrabenazine is an inhibitor of vesicular monoamine transport with a 10-fold selectivity for the VMAT2 transporter over VMAT1 (IC50 values = 0.3 M and 3.4 M, respectively). Tetrabenazine blocks D2 receptors and dopamine uptake (IC50 = 0.12 M) and inhibits serotonin transport by VMAT2 (IC50 = 300 nM). In an animal model of Huntington s disease, Tetrabenazine prevents the decline in motor control and reduces loss of striatal neurons. Tetrabenazine increases cFos expression in the thalamus and hippocampus, reduces brain connectivity and spontaneous locomotion and also causes behavioral depression.

Potent inhibitors inhibits vesicular monoamine transport depletes noradrenalin stores dopamine 5-HT Noradrenalin Transporter NET Adrenergic Transporters Monoamine Neurotransmitter DAT Dopamine Serotonin SERT reuptake 5-Hydroxytryptamine noradrenaline hunt Dopamine Transporters Adrenergic Transporters 5-HT Transporters Vesicular Monoamine Transporters 2175,

Potent inhibitor of vesicular monoamine transport

(3R,11bR)-rel-1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one

C19H27NO3

C19H27NO3

58-46-8

211

220 USD

Potent inhibitor of vesicular monoamine transport