product summary
Loading...
company name :
Tocris Bioscience
product type :
chemical
product name :
Z-VAD-FMK
catalog :
2163
quantity :
1 mg
price :
259 USD
more info or order :
citations: 32
Reference
Bae J, Jo S, Kim S, Lee J, Jeong J, Kang J, et al. Circulating Cell-Free mtDNA Contributes to AIM2 Inflammasome-Mediated Chronic Inflammation in Patients with Type 2 Diabetes. Cells. 2019;8: pubmed publisher
Uderhardt S, Martins A, Tsang J, Lämmermann T, Germain R. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 2019;177:541-555.e17 pubmed publisher
Bagnjuk K, Stöckl J, Frohlich T, Arnold G, Behr R, Berg U, et al. Necroptosis in primate luteolysis: a role for ceramide. Cell Death Discov. 2019;5:67 pubmed publisher
Shacham Silverberg V, Sar Shalom H, Goldner R, Golan Vaishenker Y, Gurwicz N, Gokhman I, et al. Phosphatidylserine is a marker for axonal debris engulfment but its exposure can be decoupled from degeneration. Cell Death Dis. 2018;9:1116 pubmed publisher
Greer Y, Porat Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde V, et al. ONC201 kills breast cancer cells in vitro by targeting mitochondria. Oncotarget. 2018;9:18454-18479 pubmed publisher
Retamal Díaz A, Weiss K, Tognarelli E, Freire M, Bueno S, Herold B, et al. US6 Gene Deletion in Herpes Simplex Virus Type 2 Enhances Dendritic Cell Function and T Cell Activation. Front Immunol. 2017;8:1523 pubmed publisher
Karabay A, Koc A, Ozkan T, Hekmatshoar Y, Sunguroglu A, Aktan F, et al. Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells. Int J Mol Sci. 2016;17: pubmed publisher
Kuang Y, El Khoueiry A, Taverna P, Ljungman M, Neamati N. Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin. Mol Oncol. 2015;9:1799-814 pubmed publisher
Moon J, Hisata S, Park M, DeNicola G, Ryter S, Nakahira K, et al. mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation. Cell Rep. 2015;12:102-115 pubmed publisher
Amantini C, Morelli M, Santoni M, Soriani A, Cardinali C, Farfariello V, et al. Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells. Oncoscience. 2015;2:395-409 pubmed
Sullivan K, Nakagawa A, Xue D, Espinosa J. Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells. Cell Cycle. 2015;14:1771-8 pubmed publisher
Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, et al. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. Cell Death Dis. 2015;6:e1629 pubmed publisher
Bonnefond M, Lambert B, Giffard F, Abeilard E, Brotin E, Louis M, et al. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation. Apoptosis. 2015;20:535-50 pubmed publisher
Silva V, Plooster M, Leung J, Cassimeris L. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Cell Cycle. 2015;14:1070-81 pubmed publisher
Hu R, Warri A, Jin L, Zwart A, Riggins R, Fang H, et al. NF-κB signaling is required for XBP1 (unspliced and spliced)-mediated effects on antiestrogen responsiveness and cell fate decisions in breast cancer. Mol Cell Biol. 2015;35:379-90 pubmed publisher
Sagher E, Hernandez L, Heywood C, Pauly G, Young M, Schneider J, et al. The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells. Cancer Cell Int. 2014;14:75 pubmed publisher
Nedvetsky P, Emmerson E, Finley J, Ettinger A, Cruz Pacheco N, Prochazka J, et al. Parasympathetic innervation regulates tubulogenesis in the developing salivary gland. Dev Cell. 2014;30:449-62 pubmed publisher
Galbiati V, Papale A, Galli C, Marinovich M, Corsini E. Role of ROS and HMGB1 in contact allergen-induced IL-18 production in human keratinocytes. J Invest Dermatol. 2014;134:2719-2727 pubmed publisher
Piao M, Kim K, Zheng J, Yao C, Cha J, Boo S, et al. The ethyl acetate fraction of Sargassum muticum attenuates ultraviolet B radiation-induced apoptotic cell death via regulation of MAPK- and caspase-dependent signaling pathways in human HaCaT keratinocytes. Pharm Biol. 2014;52:1110-8 pubmed publisher
Hight M, Cheung Y, Nickels M, Dawson E, Zhao P, Saleh S, et al. A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells. Clin Cancer Res. 2014;20:2126-35 pubmed publisher
Nicolson S, Samulski R. Recombinant adeno-associated virus utilizes host cell nuclear import machinery to enter the nucleus. J Virol. 2014;88:4132-44 pubmed publisher
Im aram A, Farrand L, Bae S, Song G, Song Y, Han J, et al. The mTORC2 component rictor contributes to cisplatin resistance in human ovarian cancer cells. PLoS ONE. 2013;8:e75455 pubmed publisher
Jahchan N, Dudley J, Mazur P, Flores N, Yang D, Palmerton A, et al. A drug repositioning approach identifies tricyclic antidepressants as inhibitors of small cell lung cancer and other neuroendocrine tumors. Cancer Discov. 2013;3:1364-77 pubmed publisher
Kim A, Kang K, Kim D, Choi Y, Lee S, Kim H, et al. A ginseng metabolite, compound K, induces autophagy and apoptosis via generation of reactive oxygen species and activation of JNK in human colon cancer cells. Cell Death Dis. 2013;4:e750 pubmed publisher
Wang H, Wu C, Cheng T, Kuo C, Tsai Y, Chiang S, et al. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro. Evid Based Complement Alternat Med. 2013;2013:857929 pubmed publisher
Kim A, Lee Y, Kang S, Kim G, Kim H, Hyun J. Cytotoxic effect of clerosterol isolated from Codium fragile on A2058 human melanoma cells. Mar Drugs. 2013;11:418-30 pubmed publisher
Cook K, Shajahan A, Warri A, Jin L, Hilakivi Clarke L, Clarke R. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness. Cancer Res. 2012;72:3337-49 pubmed publisher
Sullivan K, Padilla Just N, Henry R, Porter C, Kim J, Tentler J, et al. ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53. Nat Chem Biol. 2012;8:646-54 pubmed publisher
Vago J, Nogueira C, Tavares L, Soriani F, Lopes F, Russo R, et al. Annexin A1 modulates natural and glucocorticoid-induced resolution of inflammation by enhancing neutrophil apoptosis. J Leukoc Biol. 2012;92:249-58 pubmed publisher
Woo M, Xue K, Liu J, McBride H, Tsang B. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. J Biol Chem. 2012;287:3963-75 pubmed publisher
Lee H, Byun Y, Cho K, Kim S, Lee S, Kim H, et al. GS28 Protects Neuronal Cell Death Induced by Hydrogen Peroxide under Glutathione-Depleted Condition. Korean J Physiol Pharmacol. 2011;15:149-56 pubmed publisher
García Escudero V, Gargini R, Izquierdo M. Glioma regression in vitro and in vivo by a suicide combined treatment. Mol Cancer Res. 2008;6:407-17 pubmed publisher
product information
brand :
Tocris
master code :
2163
SKU :
2163/1
product name :
Z-VAD-FMK
description :
Cell-permeable, irreversible caspase inhibitor
target :
Inflammasomes Inhibitors
category :
Peptides
unit size :
1 mg
observed molecular weight :
467.49
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
Cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo .
catalog number base :
2163
product keywords :
Cell-permeable irreversible caspases inhibitors inhibits Proteinases Proteases Caspases Inflammasomes 2163,
extended description :
Cell-permeable, irreversible caspase inhibitor
chemical name text :
Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
formula :
C 22 H 30 FN 3 O 7
formula text :
C22H30FN3O7
cas num :
187389-52-2
2020 USD :
251
2021 USD :
259 USD
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK