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company name :
Tocris Bioscience
product type :
chemical
product name :
Z-VAD-FMK
catalog :
2163/1
quantity :
1 mg
price :
335 USD
more info or order :
citations: 52
Reference
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Leung G, Feng T, Sigoillot F, Geyer F, Shirley M, Ruddy D, et al. Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma. Mol Cancer Res. 2019;17:199-211 pubmed publisher
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Greer Y, Porat Shliom N, Nagashima K, Stuelten C, Crooks D, Koparde V, et al. ONC201 kills breast cancer cells in vitro by targeting mitochondria. Oncotarget. 2018;9:18454-18479 pubmed publisher
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Grotzke J, Kozik P, Morel J, Impens F, Pietrosemoli N, Cresswell P, et al. Sec61 blockade by mycolactone inhibits antigen cross-presentation independently of endosome-to-cytosol export. Proc Natl Acad Sci U S A. 2017;114:E5910-E5919 pubmed publisher
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Souza B, Sampaio G, Pereira C, Campos G, Sardi S, Freitas L, et al. Zika virus infection induces mitosis abnormalities and apoptotic cell death of human neural progenitor cells. Sci Rep. 2016;6:39775 pubmed publisher
Thurston T, Matthews S, Jennings E, Alix E, Shao F, Shenoy A, et al. Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death. Nat Commun. 2016;7:13292 pubmed publisher
Karabay A, Koc A, Ozkan T, Hekmatshoar Y, Sunguroglu A, Aktan F, et al. Methylsulfonylmethane Induces p53 Independent Apoptosis in HCT-116 Colon Cancer Cells. Int J Mol Sci. 2016;17: pubmed publisher
Kuang Y, El Khoueiry A, Taverna P, Ljungman M, Neamati N. Guadecitabine (SGI-110) priming sensitizes hepatocellular carcinoma cells to oxaliplatin. Mol Oncol. 2015;9:1799-814 pubmed publisher
Moon J, Hisata S, Park M, DeNicola G, Ryter S, Nakahira K, et al. mTORC1-Induced HK1-Dependent Glycolysis Regulates NLRP3 Inflammasome Activation. Cell Rep. 2015;12:102-115 pubmed publisher
Amantini C, Morelli M, Santoni M, Soriani A, Cardinali C, Farfariello V, et al. Sorafenib induces cathepsin B-mediated apoptosis of bladder cancer cells by regulating the Akt/PTEN pathway. The Akt inhibitor, perifosine, enhances the sorafenib-induced cytotoxicity against bladder cancer cells. Oncoscience. 2015;2:395-409 pubmed
Vago J, Tavares L, Garcia C, Lima K, Perucci L, Vieira Ã, et al. The role and effects of glucocorticoid-induced leucine zipper in the context of inflammation resolution. J Immunol. 2015;194:4940-50 pubmed publisher
Sullivan K, Nakagawa A, Xue D, Espinosa J. Human ACAP2 is a homolog of C. elegans CNT-1 that promotes apoptosis in cancer cells. Cell Cycle. 2015;14:1771-8 pubmed publisher
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Bonnefond M, Lambert B, Giffard F, Abeilard E, Brotin E, Louis M, et al. Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation. Apoptosis. 2015;20:535-50 pubmed publisher
Silva V, Plooster M, Leung J, Cassimeris L. A delay prior to mitotic entry triggers caspase 8-dependent cell death in p53-deficient Hela and HCT-116 cells. Cell Cycle. 2015;14:1070-81 pubmed publisher
Iitaka D, Moodley S, Shimizu H, Bai X, Liu M. PKCδ-iPLA2-PGE2-PPARγ signaling cascade mediates TNF-α induced Claudin 1 expression in human lung carcinoma cells. Cell Signal. 2015;27:568-77 pubmed publisher
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Chen L, Luo L, Lu J, Li L, Liu Y, Wang J, et al. FTY720 induces apoptosis of M2 subtype acute myeloid leukemia cells by targeting sphingolipid metabolism and increasing endogenous ceramide levels. PLoS ONE. 2014;9:e103033 pubmed publisher
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Cook K, Shajahan A, Warri A, Jin L, Hilakivi Clarke L, Clarke R. Glucose-regulated protein 78 controls cross-talk between apoptosis and autophagy to determine antiestrogen responsiveness. Cancer Res. 2012;72:3337-49 pubmed publisher
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product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2163
SKU :
2163/1
product name :
Z-VAD-FMK
description :
Cell-permeable, irreversible caspase inhibitor
target :
Inflammasomes Inhibitors
unit size :
1 mg
category :
Peptides
purity :
95%
storage :
Store at -20°C
observed molecular weight :
467.49
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo .
product keywords :
Cell-permeable irreversible caspases inhibitors inhibits Proteinases Proteases Caspases Inflammasomes 2163,
extended description :
Cell-permeable, irreversible caspase inhibitor
chemical name text :
Benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone
formula :
C22H30FN3O7
formula text :
C22H30FN3O7
cas num :
634911-81-9
USD :
321
USD 2025 :
335 USD
product details :
Cell-permeable, irreversible caspase inhibitor
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK