INCA-6 | Tocris Bioscience 2162/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

INCA-6

catalog :

2162/10

quantity :

10 mg (also 50 mg)

price :

185 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Gibson A, Hui Mingalone C, Foote A, Uchimura T, Zhang M, Zeng L. Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis. Sci Rep. 2017;7:41823 pubmed publisher
Bretz C, Savage S, Capozzi M, Suarez S, Penn J. NFAT isoforms play distinct roles in TNFÎ±-induced retinal leukostasis. Sci Rep. 2015;5:14963 pubmed publisher
Savage S, Bretz C, Penn J. RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFα. PLoS ONE. 2015;10:e0116941 pubmed publisher
Faralli J, Clark R, Filla M, Peters D. NFATc1 activity regulates the expression of myocilin induced by dexamethasone. Exp Eye Res. 2015;130:9-16 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2162

SKU :

2162/10

product name :

INCA-6

description :

Inhibitor of calcineurin-substrate association

target :

Protein Ser/Thr Phosphatase Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

95%

storage :

Store at -20°C

observed molecular weight :

284.31

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

INCA-6 is an inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.

product keywords :

inhibitors inhibits calcineurin Protein Ser/Thr Phosphatases Protein Ser/Thr Phosphatases NFAT 2162,

extended description :

Inhibitor of calcineurin-substrate association

chemical name text :

9,10-Dihydro-9,10[1 ,2 ]-benzenoanthracene-1,4-dione

formula :

C20H12O2

formula text :

C20H12O2

cas num :

3519-82-2

USD :

183

USD 2025 :

185 USD

product details :

Inhibitor of calcineurin-substrate association

more info or order :

Tocris Bioscience product webpage