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company name :
Tocris Bioscience
product type :
chemical
product name :
NSC 23766
catalog :
2161/10
quantity :
10 mg (also 50 mg)
price :
216 USD
more info or order :
citations: 64
Reference
Lionarons D, Hancock D, Rana S, East P, Moore C, Murillo M, et al. RAC1P29S Induces a Mesenchymal Phenotypic Switch via Serum Response Factor to Promote Melanoma Development and Therapy Resistance. Cancer Cell. 2019;: pubmed publisher
Carvalho J, Fortunato I, Fonseca C, Pezzarossa A, Barbacena P, Domínguez Cejudo M, et al. Non-canonical Wnt signaling regulates junctional mechanocoupling during angiogenic collective cell migration. elife. 2019;8: pubmed publisher
Wu C, Silvers C, Messing E, Lee Y. Bladder cancer extracellular vesicles drive tumorigenesis by inducing the unfolded protein response in endoplasmic reticulum of nonmalignant cells. J Biol Chem. 2019;294:3207-3218 pubmed publisher
Wisdom K, Adebowale K, Chang J, Lee J, Nam S, Desai R, et al. Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments. Nat Commun. 2018;9:4144 pubmed publisher
Ford C, NANS A, Boucrot E, Hayward R. Chlamydia exploits filopodial capture and a macropinocytosis-like pathway for host cell entry. PLoS Pathog. 2018;14:e1007051 pubmed publisher
Freudenblum J, Iglesias J, Hermann M, Walsen T, Wilfinger A, Meyer D, et al. In vivo imaging of emerging endocrine cells reveals a requirement for PI3K-regulated motility in pancreatic islet morphogenesis. Development. 2018;145: pubmed publisher
Chang T, Chen C, Lee M, Chang Y, Lu C, Lu S, et al. Paxillin facilitates timely neurite initiation on soft-substrate environments by interacting with the endocytic machinery. elife. 2017;6: pubmed publisher
Weng N, Talbot P. The P2X7 receptor is an upstream regulator of dynamic blebbing and a pluripotency marker in human embryonic stem cells. Stem Cell Res. 2017;23:39-49 pubmed publisher
Wang W, Ju Y, Zhou Q, Tang J, Li M, Zhang L, et al. The Small GTPase Rac1 Contributes to Extinction of Aversive Memories of Drug Withdrawal by Facilitating GABAA Receptor Endocytosis in the vmPFC. J Neurosci. 2017;37:7096-7110 pubmed publisher
Benedicto I, Lehmann G, Ginsberg M, Nolan D, Bareja R, Elemento O, et al. Concerted regulation of retinal pigment epithelium basement membrane and barrier function by angiocrine factors. Nat Commun. 2017;8:15374 pubmed publisher
Aragon Sanabria V, Pohler S, Eswar V, Bierowski M, Gomez E, Dong C. VE-Cadherin Disassembly and Cell Contractility in the Endothelium are Necessary for Barrier Disruption Induced by Tumor Cells. Sci Rep. 2017;7:45835 pubmed publisher
Cosgrove B, Mui K, Driscoll T, Caliari S, Mehta K, Assoian R, et al. N-cadherin adhesive interactions modulate matrix mechanosensing and fate commitment of mesenchymal stem cells. Nat Mater. 2016;15:1297-1306 pubmed publisher
Chang A, Krishnan S, Prasadarao N. The effects of cytotoxic necrotizing factor 1 expression in the uptake of Escherichia coli K1 by macrophages and the onset of meningitis in newborn mice. Virulence. 2016;7:806-18 pubmed publisher
Yang Y, Chen Q, Liu A, Xu X, Han J, Qiu H. Synergism of MSC-secreted HGF and VEGF in stabilising endothelial barrier function upon lipopolysaccharide stimulation via the Rac1 pathway. Stem Cell Res Ther. 2015;6:250 pubmed publisher
Abedini A, Zamberlam G, Lapointe E, Tourigny C, Boyer A, Paquet M, et al. WNT5a is required for normal ovarian follicle development and antagonizes gonadotropin responsiveness in granulosa cells by suppressing canonical WNT signaling. FASEB J. 2016;30:1534-47 pubmed publisher
Gao Q, Yao W, Wang J, Yang T, Liu C, Tao Y, et al. Post-training activation of Rac1 in the basolateral amygdala is required for the formation of both short-term and long-term auditory fear memory. Front Mol Neurosci. 2015;8:65 pubmed publisher
Chun K, Shim M. EP2 Induces p38 Phosphorylation via the Activation of Src in HEK 293 Cells. Biomol Ther (Seoul). 2015;23:539-48 pubmed publisher
Kassmer S, Rodriguez D, Langenbacher A, Bui C, De Tomaso A. Migration of germline progenitor cells is directed by sphingosine-1-phosphate signalling in a basal chordate. Nat Commun. 2015;6:8565 pubmed publisher
Lomakin A, Lee K, Han S, Bui D, Davidson M, Mogilner A, et al. Competition for actin between two distinct F-actin networks defines a bistable switch for cell polarization. Nat Cell Biol. 2015;17:1435-45 pubmed publisher
Alves M, Fuhler G, Queiroz K, Scholma J, Goorden S, Anink J, et al. PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex. Sci Rep. 2015;5:14534 pubmed publisher
Cabet E, Batonnet Pichon S, Delort F, Gausserès B, Vicart P, Lilienbaum A. Antioxidant Treatment and Induction of Autophagy Cooperate to Reduce Desmin Aggregation in a Cellular Model of Desminopathy. PLoS ONE. 2015;10:e0137009 pubmed publisher
Tsuchiya A, Kanno T, Shimizu T, Tanaka A, Nishizaki T. Rac1 and ROCK are implicated in the cell surface delivery of GLUT4 under the control of the insulin signal mimetic diDCP-LA-PE. J Pharmacol Sci. 2015;128:179-84 pubmed publisher
Serra N, Rosales R, Masana L, Vallvé J. Simvastatin Increases Fibulin-2 Expression in Human Coronary Artery Smooth Muscle Cells via RhoA/Rho-Kinase Signaling Pathway Inhibition. PLoS ONE. 2015;10:e0133875 pubmed publisher
Gibon J, Buckley S, Unsain N, Kaartinen V, Séguéla P, Barker P. proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons. J Neurosci. 2015;35:9741-53 pubmed publisher
Yao H, Shi W, Wu J, Xu C, Wang J, Shao Y, et al. Endothelial Rac1 is essential for hematogenous metastasis to the lung. Oncotarget. 2015;6:17501-13 pubmed
Yevick H, Duclos G, Bonnet I, Silberzan P. Architecture and migration of an epithelium on a cylindrical wire. Proc Natl Acad Sci U S A. 2015;112:5944-9 pubmed publisher
Lee H, Cheerathodi M, Chaki S, Reyes S, Zheng Y, Lu Z, et al. Protein tyrosine phosphatase-PEST and ?8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells. Mol Cell Biol. 2015;35:1401-13 pubmed publisher
Wang Y, Kunit T, Ciotkowska A, Rutz B, Schreiber A, Strittmatter F, et al. Inhibition of prostate smooth muscle contraction and prostate stromal cell growth by the inhibitors of Rac, NSC23766 and EHT1864. Br J Pharmacol. 2015;172:2905-17 pubmed publisher
Hou H, Chávez A, Wang C, Yang H, Gu H, Siddoway B, et al. The Rac1 inhibitor NSC23766 suppresses CREB signaling by targeting NMDA receptor function. J Neurosci. 2014;34:14006-12 pubmed publisher
Uotila L, Jahan F, Soto Hinojosa L, Melandri E, Grönholm M, Gahmberg C. Specific phosphorylations transmit signals from leukocyte β2 to β1 integrins and regulate adhesion. J Biol Chem. 2014;289:32230-42 pubmed publisher
Kenny H, Chiang C, White E, Schryver E, Habis M, Romero I, et al. Mesothelial cells promote early ovarian cancer metastasis through fibronectin secretion. J Clin Invest. 2014;124:4614-28 pubmed publisher
Lin L, Jin Y, Mars W, Reeves W, Hu K. Myeloid-derived tissue-type plasminogen activator promotes macrophage motility through FAK, Rac1, and NF-?B pathways. Am J Pathol. 2014;184:2757-67 pubmed publisher
Chen R, Fu M, Zhang G, Zhou Y, Zhu S, Liu J, et al. Rac1 regulates skin tumors by regulation of keratin 17 through recruitment and interaction with CD11b+Gr1+ cells. Oncotarget. 2014;5:4406-17 pubmed
Lichius A, Goryachev A, Fricker M, Obara B, Castro Longoria E, Read N. CDC-42 and RAC-1 regulate opposite chemotropisms in Neurospora crassa. J Cell Sci. 2014;127:1953-65 pubmed publisher
Kageyama Y, Doi T, Matsushima Nishiwaki R, Iida Y, Akamatsu S, Kondo A, et al. Involvement of Rac in thromboxane A2?induced human platelet activation: regulation of sCD40 ligand release and PDGF?AB secretion. Mol Med Rep. 2014;10:107-12 pubmed publisher
Hergueta Redondo M, Sarrió D, Molina Crespo Ã, Megias D, Mota A, Rojo Sebastián A, et al. Gasdermin-B promotes invasion and metastasis in breast cancer cells. PLoS ONE. 2014;9:e90099 pubmed publisher
Sakurai T, Woolls M, Jin S, Murakami M, Simons M. Inter-cellular exchange of cellular components via VE-cadherin-dependent trans-endocytosis. PLoS ONE. 2014;9:e90736 pubmed publisher
Huttunen M, Waris M, Kajander R, Hyypia T, Marjomaki V. Coxsackievirus A9 infects cells via nonacidic multivesicular bodies. J Virol. 2014;88:5138-51 pubmed publisher
Zhu S, Lu P, Liu H, Chen P, Wu Y, Wang Y, et al. Inhibition of Rac1 activity by controlled release of NSC23766 from chitosan microspheres effectively ameliorates osteoarthritis development in vivo. Ann Rheum Dis. 2015;74:285-93 pubmed publisher
Moore R, Theveneau E, Pozzi S, Alexandre P, Richardson J, Merks A, et al. Par3 controls neural crest migration by promoting microtubule catastrophe during contact inhibition of locomotion. Development. 2013;140:4763-75 pubmed publisher
Farrow M, Chumbler N, Lapierre L, Franklin J, Rutherford S, Goldenring J, et al. Clostridium difficile toxin B-induced necrosis is mediated by the host epithelial cell NADPH oxidase complex. Proc Natl Acad Sci U S A. 2013;110:18674-9 pubmed publisher
Harrison S, Knifley T, Chen M, O Connor K. LPA, HGF, and EGF utilize distinct combinations of signaling pathways to promote migration and invasion of MDA-MB-231 breast carcinoma cells. BMC Cancer. 2013;13:501 pubmed publisher
McNary S, Athanasiou K, Reddi A. Transforming growth factor ?-induced superficial zone protein accumulation in the surface zone of articular cartilage is dependent on the cytoskeleton. Tissue Eng Part A. 2014;20:921-9 pubmed publisher
Minz Dub A, Kokkelink L, Tudzynski B, Tudzynski P, Sharon A. Involvement of Botrytis cinerea small GTPases BcRAS1 and BcRAC in differentiation, virulence, and the cell cycle. Eukaryot Cell. 2013;12:1609-18 pubmed publisher
Martin H, Mali R, Ma P, Chatterjee A, Ramdas B, Sims E, et al. Pak and Rac GTPases promote oncogenic KIT-induced neoplasms. J Clin Invest. 2013;123:4449-63 pubmed publisher
Zhu W, Nelson C. PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively. Dev Biol. 2013;379:235-45 pubmed publisher
Wan Q, Cho E, Yokota H, Na S. Rac1 and Cdc42 GTPases regulate shear stress-driven ?-catenin signaling in osteoblasts. Biochem Biophys Res Commun. 2013;433:502-7 pubmed publisher
Prowse P, Elliott C, Hutter J, Hamilton D. Inhibition of Rac and ROCK signalling influence osteoblast adhesion, differentiation and mineralization on titanium topographies. PLoS ONE. 2013;8:e58898 pubmed publisher
Ke K, Sul O, Kim W, Lee M, Ko M, Suh J, et al. Overexpression of developmentally regulated GTP-binding protein-2 increases bone loss. Am J Physiol Endocrinol Metab. 2013;304:E703-10 pubmed publisher
Tseng P, Judy J, Di Carlo D. Magnetic nanoparticle-mediated massively parallel mechanical modulation of single-cell behavior. Nat Methods. 2012;9:1113-9 pubmed publisher
Sun H, Zhuang G, Chai L, Wang Z, Johnson D, Ma Y, et al. TIPE2 controls innate immunity to RNA by targeting the phosphatidylinositol 3-kinase-Rac pathway. J Immunol. 2012;189:2768-73 pubmed publisher
Tabdili H, Barry A, Langer M, Chien Y, Shi Q, Lee K, et al. Cadherin point mutations alter cell sorting and modulate GTPase signaling. J Cell Sci. 2012;125:3299-309 pubmed publisher
Tang A, Campbell W, Nithipatikom K. ROCK1 feedback regulation of the upstream small GTPase RhoA. Cell Signal. 2012;24:1375-80 pubmed publisher
Akhmetshina A, Palumbo K, Dees C, Bergmann C, Venalis P, Zerr P, et al. Activation of canonical Wnt signalling is required for TGF-?-mediated fibrosis. Nat Commun. 2012;3:735 pubmed publisher
Goodnough J, Ramos E, Nemeth E, Ganz T. Inhibition of hepcidin transcription by growth factors. Hepatology. 2012;56:291-9 pubmed publisher
Grönholm M, Jahan F, Marchesan S, Karvonen U, Aatonen M, Narumanchi S, et al. TCR-induced activation of LFA-1 involves signaling through Tiam1. J Immunol. 2011;187:3613-9 pubmed publisher
Gulhati P, Bowen K, Liu J, Stevens P, Rychahou P, Chen M, et al. mTORC1 and mTORC2 regulate EMT, motility, and metastasis of colorectal cancer via RhoA and Rac1 signaling pathways. Cancer Res. 2011;71:3246-56 pubmed publisher
Fort P, Gu mar L, Vignal E, Morin N, Notarnicola C, de Santa Barbara P, et al. Activity of the RhoU/Wrch1 GTPase is critical for cranial neural crest cell migration. Dev Biol. 2011;350:451-63 pubmed publisher
Dwivedi S, Pandey D, Khandoga A, Brandl R, Siess W. Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque. J Transl Med. 2010;8:128 pubmed publisher
McHenry P, Sears J, Herrick M, Chang P, Heckman Stoddard B, Rybarczyk M, et al. P190B RhoGAP has pro-tumorigenic functions during MMTV-Neu mammary tumorigenesis and metastasis. Breast Cancer Res. 2010;12:R73 pubmed publisher
Gomez E, Chen Q, Gjorevski N, Nelson C. Tissue geometry patterns epithelial-mesenchymal transition via intercellular mechanotransduction. J Cell Biochem. 2010;110:44-51 pubmed publisher
Eum S, Andras I, Hennig B, Toborek M. NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells. Toxicol Appl Pharmacol. 2009;240:299-305 pubmed publisher
Rex C, Chen L, Sharma A, Liu J, Babayan A, Gall C, et al. Different Rho GTPase-dependent signaling pathways initiate sequential steps in the consolidation of long-term potentiation. J Cell Biol. 2009;186:85-97 pubmed publisher
Brown D, Price L. Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. Vet Microbiol. 2007;120:328-33 pubmed
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2161
SKU :
2161/10
product name :
NSC 23766
description :
Selective inhibitor of Rac1-GEF interaction; antioncogenic
target :
Rho GTPase Inhibitors
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
99%
storage :
Desiccate at RT
observed molecular weight :
530.97
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
NSC 23766 is a selective inhibitor of Rac1-GEF interaction. NSC 23766 prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC50 ~ 50 u M) without affecting Cdc42 or RhoA activation. The compound inhibits Rac1-mediated cell functions and is reported to reverse tumor cell phenotypes in prostate cancer cells. NSC 23766 also inhibits mammary carcinoma cell invasion in vitro and inhibits mammary tumor progression and metastasis in a mouse model.
product keywords :
Selective inhibitors inhibits Rac1-GEF interaction antioncogenic G Proteins Small NSC23766 1177865-17-6 Rho 2161,
extended description :
Selective inhibitor of Rac1-GEF interaction; antioncogenic
chemical name text :
N6-[2-[[4-(Diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine trihydrochloride
formula :
C24H35N7.3HCl
formula text :
C24H35N7.3HCl
cas num :
1177865-17-6
USD :
207
USD 2025 :
216 USD
product details :
Selective inhibitor of Rac1-GEF interaction; antioncogenic
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK