Bax channel blocker | Tocris Bioscience 2160 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Bax channel blocker

catalog :

2160

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Ono A, Sano O, Kazetani K, Muraki T, Imamura K, Sumi H, et al. Feedback activation of AMPK-mediated autophagy acceleration is a key resistance mechanism against SCD1 inhibitor-induced cell growth inhibition. PLoS ONE. 2017;12:e0181243 pubmed publisher
Sano O, Kazetani K, Funata M, Fukuda Y, Matsui J, Iwata H. Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition. FEBS Lett. 2016;590:1576-85 pubmed publisher

product information

brand :

Tocris

master code :

2160

SKU :

2160/10

product name :

Bax channel blocker

description :

Allosteric inhibitor of Bax channel activation

target :

Bcl-2 Family Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

540.12

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Allosteric inhibitor of Bax channel activation. Binds inactive Bax at allosteric site and inhibits tBID-mediated Bax activation (IC50 = 3.3 M). Selectively inhibits Bax-dependent apoptosis. Potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 u M).

catalog number base :

2160

product keywords :

inhibitors inhibits Bax-mediated mitochondrial cytochrome c release Bcl-2 Family allosteric activation BAI1 Bcl-2 Family 2160,

extended description :

Allosteric inhibitor of Bax channel activation

chemical name text :

3,6-Dibromo- -(1-piperazinylmethyl)-9H-carbazole-9-ethanol dihydrochloride

formula :

C 19 H 21 Br 2 N 3 O.2HCl

formula text :

C19H21Br2N3O.2HCl

cas num :

329349-20-4

2020 USD :

187

2021 USD :

195 USD

alt names :

BAI1

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage