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company name :
Tocris Bioscience
product type :
chemical
product name :
MRS 2500 tetraammonium salt
catalog :
2159/1
quantity :
1 mg
price :
474 USD
more info or order :
citations: 21
Reference
Babola T, Li S, Wang Z, Kersbergen C, Elgoyhen A, Coate T, et al. Purinergic Signaling Controls Spontaneous Activity in the Auditory System throughout Early Development. J Neurosci. 2021;41:594-612 pubmed publisher
Babola T, Kersbergen C, Wang H, Bergles D. Purinergic signaling in cochlear supporting cells reduces hair cell excitability by increasing the extracellular space. elife. 2020;9: pubmed publisher
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
Ryu J, Choe S, Ryu S, Park E, Lee B, Kim T, et al. Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells. Oncotarget. 2017;8:4181-4195 pubmed publisher
Baron L, Gombault A, Fanny M, Villeret B, Savigny F, Guillou N, et al. The NLRP3 inflammasome is activated by nanoparticles through ATP, ADP and adenosine. Cell Death Dis. 2015;6:e1629 pubmed publisher
Braganhol E, Kukulski F, Lévesque S, Fausther M, Lavoie E, Zanotto Filho A, et al. Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells. Biochim Biophys Acta. 2015;1852:120-30 pubmed publisher
Kurahashi M, MUTAFOVA YAMBOLIEVA V, Koh S, Sanders K. Platelet-derived growth factor receptor-?-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles. Am J Physiol Cell Physiol. 2014;307:C561-70 pubmed publisher
Erdelyi M, Simon J, Barnard E, Kaminski C. Analyzing receptor assemblies in the cell membrane using fluorescence anisotropy imaging with TIRF microscopy. PLoS ONE. 2014;9:e100526 pubmed publisher
Helms C, Marvel M, Zhao W, Stahle M, Vest R, Kato G, et al. Mechanisms of hemolysis-associated platelet activation. J Thromb Haemost. 2013;11:2148-54 pubmed publisher
Ilatovskaya D, Palygin O, Levchenko V, Staruschenko A. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol. 2013;305:C1050-9 pubmed publisher
Alefishat E, Alexander S, Ralevic V. Antagonism of P2Y1-induced vasorelaxation by acyl CoA: a critical role for palmitate and 3'-phosphate. Br J Pharmacol. 2013;168:1911-22 pubmed publisher
Fei G, Fang X, Wang G, Liu S, Wang X, Xia Y, et al. Neurogenic mucosal bicarbonate secretion in guinea pig duodenum. Br J Pharmacol. 2013;168:880-90 pubmed publisher
Gao Z, Wei Q, Jayasekara M, Jacobson K. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013;9:31-40 pubmed publisher
Duffy A, Cobine C, Keef K. Changes in neuromuscular transmission in the W/W(v) mouse internal anal sphincter. Neurogastroenterol Motil. 2012;24:e41-55 pubmed publisher
Hwang S, Durnin L, Dwyer L, Rhee P, Ward S, Koh S, et al. ?-nicotinamide adenine dinucleotide is an enteric inhibitory neurotransmitter in human and nonhuman primate colons. Gastroenterology. 2011;140:608-617.e6 pubmed publisher
Gorman M, Rooke G, Savage M, Jayasekara M, Jacobson K, Feigl E. Adenine nucleotide control of coronary blood flow during exercise. Am J Physiol Heart Circ Physiol. 2010;299:H1981-9 pubmed publisher
Ham M, Mizumori M, Watanabe C, Wang J, Inoue T, Nakano T, et al. Endogenous luminal surface adenosine signaling regulates duodenal bicarbonate secretion in rats. J Pharmacol Exp Ther. 2010;335:607-13 pubmed publisher
Bradley E, Kadima S, Drumm B, Hollywood M, Thornbury K, McHale N, et al. Novel excitatory effects of adenosine triphosphate on contractile and pacemaker activity in rabbit urethral smooth muscle. J Urol. 2010;183:801-11 pubmed publisher
Högberg C, Erlinge D, Braun O. Mild hypothermia does not attenuate platelet aggregation and may even increase ADP-stimulated platelet aggregation after clopidogrel treatment. Thromb J. 2009;7:2 pubmed publisher
Konopatskaya O, Gilio K, Harper M, Zhao Y, Cosemans J, Karim Z, et al. PKCalpha regulates platelet granule secretion and thrombus formation in mice. J Clin Invest. 2009;119:399-407 pubmed publisher
Ohtani M, Suzuki J, Jacobson K, Oka T. Evidence for the possible involvement of the P2Y(6) receptor in Ca (2+) mobilization and insulin secretion in mouse pancreatic islets. Purinergic Signal. 2008;4:365-75 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2159
SKU :
2159/1
product name :
MRS 2500 tetraammonium salt
description :
Highly potent and selective P2Y1 antagonist
target :
P2Y Receptor Antagonists
unit size :
1 mg
category :
Small Molecules
purity :
96%
storage :
Store at -20°C
observed molecular weight :
629.29
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MRS 2500 tetraammonium salt is a highly potent and selective antagonist of the platelet P2Y1 receptor (Ki = 0.78 nM). Inhibits ADP-induced aggregation of human platelets with an IC50 value of 0.95 nM. Inhibits the upregulation of NTPDase1 by ATP S. Prevents thrombus formation in vivo .
product keywords :
potent selective P2Y1 antagonists Receptors Purinergic purinoceptors MRS2500 prevents thrombus formation antagonises inhibitors inhibits Purinergic P2Y Receptors 2159,
extended description :
Highly potent and selective P2Y1 antagonist
chemical name text :
(1R*,2S*)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt
formula :
C13H18N5O8P2I.4NH3
formula text :
C13H18N5O8P2I.4NH3
cas num :
630103-23-0
USD :
454
USD 2025 :
474 USD
product details :
Highly potent and selective P2Y1 antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK