MRS 2279 | Tocris Bioscience 2158/1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MRS 2279

catalog :

2158/1

quantity :

1 mg

price :

518 USD

citations: 8

Reference
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
Hiller S, Heldmann S, Richter K, Jurastow I, Küllmar M, Hecker A, et al. ?-Nicotinamide Adenine Dinucleotide (?-NAD) Inhibits ATP-Dependent IL-1? Release from Human Monocytic Cells. Int J Mol Sci. 2018;19: pubmed publisher
Wilkaniec A, Gassowska M, Czapski G, Cieslik M, Sulkowski G, Adamczyk A. P2X7 receptor-pannexin 1 interaction mediates extracellular alpha-synuclein-induced ATP release in neuroblastoma SH-SY5Y cells. Purinergic Signal. 2017;13:347-361 pubmed publisher
Walsh T, Harper M, Poole A. SDF-1Î± is a novel autocrine activator of platelets operating through its receptor CXCR4. Cell Signal. 2015;27:37-46 pubmed publisher
Goggs R, Harper M, Pope R, Savage J, Williams C, Mundell S, et al. RhoG protein regulates platelet granule secretion and thrombus formation in mice. J Biol Chem. 2013;288:34217-29 pubmed publisher
Ohtomo K, Shatos M, Vrouvlianis J, Li D, Hodges R, Dartt D. Increase of intracellular Ca2+ by purinergic receptors in cultured rat lacrimal gland myoepithelial cells. Invest Ophthalmol Vis Sci. 2011;52:9503-15 pubmed publisher
Kuboyama K, Harada H, Tozaki Saitoh H, Tsuda M, Ushijima K, Inoue K. Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia. J Cereb Blood Flow Metab. 2011;31:1930-41 pubmed publisher
Harper M, Poole A. Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets. J Biol Chem. 2010;285:19865-73 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2158

SKU :

2158/1

product name :

MRS 2279

description :

Selective, high affinity P2Y1 antagonist

target :

P2Y Receptor Antagonists

unit size :

1 mg

category :

Small Molecules

purity :

98%

storage :

Store at -20°C

observed molecular weight :

503.78

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

MRS 2279 is a selective, high affinity competitive antagonist of the P2Y1 receptor (Ki = 2.5 nM; IC50 = 51.6 nM). Fails to block nucleotide signaling at most other P2Y receptors (P2Y2, P2Y4, P2Y6, P2Y11 and P2Y12) and potently inhibits ADP-induced aggregation of human blood platelets in vitro (pKB = 8.05).

product keywords :

Selective high affinity P2Y1 antagonists Receptors Purinergic purinoceptors MRS2279 264611-07-6 367909-40-8 antagonises inhibitors inhibits Purinergic P2Y Receptors 2158,

extended description :

Selective, high affinity P2Y1 antagonist

chemical name text :

(1R*,2S*)-4-[2-Chloro-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester diammonium salt

formula :

C13H18ClN5O8P2.2NH3

formula text :

C13H18ClN5O8P2.2NH3

cas num :

2387505-47-5

USD :

502

USD 2025 :

518 USD

product details :

Selective, high affinity P2Y1 antagonist