MRS 2365 | Tocris Bioscience 2157 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

MRS 2365

catalog :

2157

quantity :

1 mg

price :

389 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Zhang W, Bonadiman A, Ciorraga M, Benitez M, Garrido J. P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development. Front Cell Neurosci. 2019;13:152 pubmed publisher
Stefanini L, Paul D, Robledo R, Chan E, Getz T, Campbell R, et al. RASA3 is a critical inhibitor of RAP1-dependent platelet activation. J Clin Invest. 2015;125:1419-32 pubmed publisher
Kurahashi M, MUTAFOVA YAMBOLIEVA V, Koh S, Sanders K. Platelet-derived growth factor receptor-?-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles. Am J Physiol Cell Physiol. 2014;307:C561-70 pubmed publisher
Koch H, Bespalov A, Drescher K, Franke H, Krügel U. Impaired cognition after stimulation of P2Y1 receptors in the rat medial prefrontal cortex. Neuropsychopharmacology. 2015;40:305-14 pubmed publisher
Ilatovskaya D, Palygin O, Levchenko V, Staruschenko A. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol. 2013;305:C1050-9 pubmed publisher
Shabir S, Cross W, Kirkwood L, Pearson J, Appleby P, Walker D, et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am J Physiol Renal Physiol. 2013;305:F396-406 pubmed publisher
Gao Z, Wei Q, Jayasekara M, Jacobson K. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013;9:31-40 pubmed publisher
Chandaka G, Salzer I, Drobny H, Boehm S, Schicker K. Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y(1) receptors. Br J Pharmacol. 2011;164:1522-33 pubmed publisher
Kuboyama K, Harada H, Tozaki Saitoh H, Tsuda M, Ushijima K, Inoue K. Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia. J Cereb Blood Flow Metab. 2011;31:1930-41 pubmed publisher
Filippov A, Simon J, Barnard E, Brown D. The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons. J Neurosci. 2010;30:11068-72 pubmed publisher
Mamedova L, Wang R, Besada P, Liang B, Jacobson K. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacol Res. 2008;58:232-9 pubmed publisher

product information

brand :

Tocris

master code :

2157

SKU :

2157/1

product name :

MRS 2365

description :

Highly potent and selective P2Y1 agonist

target :

P2Y Receptor Agonists

category :

Small Molecules

unit size :

1 mg

purity :

98%

observed molecular weight :

549.28

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly potent, selective P2Y1 receptor agonist (EC50 = 0.4 nM). Displays no activity at P2Y12 receptors and only very low agonist activity at P2Y13 receptors (at concentrations up to 1 u M). Increases the upregulation of NTPDase1 by ATP S.

catalog number base :

2157

product keywords :

potent selective P2Y1 agonists Receptors Purinergic purinoceptors MRS2365 436847-09-5 Purinergic P2Y Receptors 2157,

extended description :

Highly potent and selective P2Y1 agonist

chemical name text :

[[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt

formula :

C 13 H 16 N 5 O 9 P 2 SNa 3

formula text :

C13H16N5O9P2SNa3

2020 USD :

377

2021 USD :

389 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage