product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
MRS 2365
catalog :
2157/1
quantity :
1 mg
price :
503 USD
more info or order :
citations: 13
Reference
Yang C, Hung S, Hsu S, Macdonald I, Lin J, Luo S, et al. Inhibiting the LPS-induced enhancement of mEPSC frequency in superficial dorsal horn neurons may serve as an electrophysiological model for alleviating pain. Sci Rep. 2019;9:16032 pubmed publisher
Zhang W, Bonadiman A, Ciorraga M, Benitez M, Garrido J. P2Y1 Purinergic Receptor Modulate Axon Initial Segment Initial Development. Front Cell Neurosci. 2019;13:152 pubmed publisher
Wu J, Cheng Y, Zhang R, Liu D, Luo Y, Chen K, et al. P2Y1R is involved in visceral hypersensitivity in rats with experimental irritable bowel syndrome. World J Gastroenterol. 2017;23:6339-6349 pubmed publisher
Stefanini L, Paul D, Robledo R, Chan E, Getz T, Campbell R, et al. RASA3 is a critical inhibitor of RAP1-dependent platelet activation. J Clin Invest. 2015;125:1419-32 pubmed publisher
Kurahashi M, MUTAFOVA YAMBOLIEVA V, Koh S, Sanders K. Platelet-derived growth factor receptor-?-positive cells and not smooth muscle cells mediate purinergic hyperpolarization in murine colonic muscles. Am J Physiol Cell Physiol. 2014;307:C561-70 pubmed publisher
Koch H, Bespalov A, Drescher K, Franke H, Krügel U. Impaired cognition after stimulation of P2Y1 receptors in the rat medial prefrontal cortex. Neuropsychopharmacology. 2015;40:305-14 pubmed publisher
Ilatovskaya D, Palygin O, Levchenko V, Staruschenko A. Pharmacological characterization of the P2 receptors profile in the podocytes of the freshly isolated rat glomeruli. Am J Physiol Cell Physiol. 2013;305:C1050-9 pubmed publisher
Shabir S, Cross W, Kirkwood L, Pearson J, Appleby P, Walker D, et al. Functional expression of purinergic P2 receptors and transient receptor potential channels by the human urothelium. Am J Physiol Renal Physiol. 2013;305:F396-406 pubmed publisher
Gao Z, Wei Q, Jayasekara M, Jacobson K. The role of P2Y(14) and other P2Y receptors in degranulation of human LAD2 mast cells. Purinergic Signal. 2013;9:31-40 pubmed publisher
Chandaka G, Salzer I, Drobny H, Boehm S, Schicker K. Facilitation of transmitter release from rat sympathetic neurons via presynaptic P2Y(1) receptors. Br J Pharmacol. 2011;164:1522-33 pubmed publisher
Kuboyama K, Harada H, Tozaki Saitoh H, Tsuda M, Ushijima K, Inoue K. Astrocytic P2Y(1) receptor is involved in the regulation of cytokine/chemokine transcription and cerebral damage in a rat model of cerebral ischemia. J Cereb Blood Flow Metab. 2011;31:1930-41 pubmed publisher
Filippov A, Simon J, Barnard E, Brown D. The scaffold protein NHERF2 determines the coupling of P2Y1 nucleotide and mGluR5 glutamate receptor to different ion channels in neurons. J Neurosci. 2010;30:11068-72 pubmed publisher
Mamedova L, Wang R, Besada P, Liang B, Jacobson K. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacol Res. 2008;58:232-9 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
2157
SKU :
2157/1
product name :
MRS 2365
description :
Highly potent and selective P2Y1 agonist
target :
P2Y Receptor Agonists
unit size :
1 mg
category :
Small Molecules
purity :
98%
storage :
Store at -20°C
observed molecular weight :
549.28
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MRS 2365 is a highly potent, selective P2Y1 receptor agonist (EC50 = 0.4 nM). Displays no activity at P2Y12 receptors and only very low agonist activity at P2Y13 receptors (at concentrations up to 1 u M). Increases the upregulation of NTPDase1 by ATP S.
product keywords :
potent selective P2Y1 agonists Receptors Purinergic purinoceptors MRS2365 436847-09-5 Purinergic P2Y Receptors 2157,
extended description :
Highly potent and selective P2Y1 agonist
chemical name text :
[[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt
formula :
C13H16N5O9P2SNa3
formula text :
C13H16N5O9P2SNa3
USD :
482
USD 2025 :
503 USD
product details :
Highly potent and selective P2Y1 agonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK