Embelin | Tocris Bioscience 2156/10 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Embelin

catalog :

2156/10

quantity :

10 mg

price :

147 USD

citations: 1

Reference
Barbelanne M, Song J, Ahmadzai M, Tsang W. Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis. Hum Mol Genet. 2013;22:2482-94 pubmed publisher

product information

brand :

Tocris

master code :

2156

SKU :

2156/10

product name :

Embelin

unit size :

10 mg

description :

Highly potent and selective P2Y1 agonist

target :

IAP Inhibitors

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

294.39

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Embelin is a cell-permeable, non-peptide inhibitor of X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 u M in competition binding assay with Smac peptide); binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Inhibits cell growth, induces apoptosis and activates caspase-9 in prostate cancer cells (IC50 4 - 6 u M), but has a weaker effect on normal prostate cells (IC50 = 19 - 20 u M). Overcomes the protective effect of XIAP on apoptosis in XIAP-transfected Jurkat cells. Anti-tumor, analgesic and anti-inflammatory in vivo .

extended description :

Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor

chemical name text :

2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione

formula :

C 17 H 26 O 4

formula text :

C17H26O4

cas num :

550-24-3

USD :

139

Jul-22 :

147 USD

product details :

Inhibitor of X-linked inhibitor of apoptosis (XIAP); cell-permeable and antitumor

sizes available :

10 mg (also 50 mg)