API-2 | Tocris Bioscience 2151/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

API-2

catalog :

2151/10

quantity :

10 mg

price :

400 USD

more info or order :

Tocris Bioscience product webpage

citations: 21

Reference
Yuan X, Cao X, Yang S. IFT80 is required for stem cell proliferation, differentiation, and odontoblast polarization during tooth development. Cell Death Dis. 2019;10:63 pubmed publisher
Suarez C, Wu J, Badve S, Sparano J, Kaliney W, Littlepage L. The AKT inhibitor triciribine in combination with paclitaxel has order-specific efficacy against Zfp217-induced breast cancer chemoresistance. Oncotarget. 2017;8:108534-108547 pubmed publisher
Ali R, Samman N, Al Zahrani H, Nehdi A, Rahman S, Khan A, et al. Isolation and characterization of a new naturally immortalized human breast carcinoma cell line, KAIMRC1. BMC Cancer. 2017;17:803 pubmed publisher
ArquÃ©s O, Chicote I, Puig I, Tenbaum S, ArgilÃ©s G, Dienstmann R, et al. Tankyrase Inhibition Blocks Wnt/Î²-Catenin Pathway and Reverts Resistance to PI3K and AKT Inhibitors in the Treatment of Colorectal Cancer. Clin Cancer Res. 2016;22:644-56 pubmed publisher
Kana K, Song H, Laschinger C, Zandstra P, Radisic M. PI3K Phosphorylation Is Linked to Improved Electrical Excitability in an In Vitro Engineered Heart Tissue Disease Model System. Tissue Eng Part A. 2015;21:2379-89 pubmed publisher
Rosenberg S, Niglio S, Salehomoum N, Chan J, Jeong B, Wen Y, et al. Targeting Glutamatergic Signaling and the PI3 Kinase Pathway to Halt Melanoma Progression. Transl Oncol. 2015;8:1-9 pubmed publisher
Kulkarni N, Yi Z, Huehnken C, Agerberth B, Gudmundsson G. Phenylbutyrate induces cathelicidin expression via the vitamin D receptor: Linkage to inflammatory and growth factor cytokines pathways. Mol Immunol. 2015;63:530-9 pubmed
Shravah J, Wang B, Pavlovic M, Kumar U, Chen D, Luo H, et al. Propofol mediates signal transducer and activator of transcription 3 activation and crosstalk with phosphoinositide 3-kinase/AKT. JAKSTAT. 2014;3:e29554 pubmed publisher
Kuo T, Chen T, Yan S, Foo F, Ching C, McQueen A, et al. Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin. J Lipid Res. 2014;55:919-28 pubmed publisher
Puig I, Chicote I, Tenbaum S, Arqu xe9 s O, Herance J, Gispert J, et al. A personalized preclinical model to evaluate the metastatic potential of patient-derived colon cancer initiating cells. Clin Cancer Res. 2013;19:6787-801 pubmed publisher
Liu Y, Xu Y, Sun J, Ma A, Zhang F, Xia S, et al. AKT hyperactivation confers a Th1 phenotype in thymic Treg cells deficient in TGF-? receptor II signaling. Eur J Immunol. 2014;44:521-32 pubmed publisher
Robertson A, Coluccio A, Jensen S, Rydlizky K, Coffman J. Sea urchin akt activity is Runx-dependent and required for post-cleavage stage cell division. Biol Open. 2013;2:472-8 pubmed publisher
Tenbaum S, Ordóñez Morán P, Puig I, Chicote I, Arqués O, Landolfi S, et al. ?-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer. Nat Med. 2012;18:892-901 pubmed publisher
Woo M, Xue K, Liu J, McBride H, Tsang B. Calpain-mediated processing of p53-associated parkin-like cytoplasmic protein (PARC) affects chemosensitivity of human ovarian cancer cells by promoting p53 subcellular trafficking. J Biol Chem. 2012;287:3963-75 pubmed publisher
Duan S, Skaar J, Kuchay S, Toschi A, Kanarek N, Ben Neriah Y, et al. mTOR generates an auto-amplification loop by triggering the ?TrCP- and CK1?-dependent degradation of DEPTOR. Mol Cell. 2011;44:317-24 pubmed publisher
Barber A, Sentman C. NKG2D receptor regulates human effector T-cell cytokine production. Blood. 2011;117:6571-81 pubmed publisher
Jackson C, Welch H, Bellamy T. Control of cerebellar long-term potentiation by P-Rex-family guanine-nucleotide exchange factors and phosphoinositide 3-kinase. PLoS ONE. 2010;5:e11962 pubmed publisher
Liu S, Shen H, Xu M, Liu O, Zhao L, Liu S, et al. FRP inhibits ox-LDL-induced endothelial cell apoptosis through an Akt-NF-{kappa}B-Bcl-2 pathway and inhibits endothelial cell apoptosis in an apoE-knockout mouse model. Am J Physiol Endocrinol Metab. 2010;299:E351-63 pubmed publisher
Sunters A, Armstrong V, Zaman G, Kypta R, Kawano Y, Lanyon L, et al. Mechano-transduction in osteoblastic cells involves strain-regulated estrogen receptor alpha-mediated control of insulin-like growth factor (IGF) I receptor sensitivity to Ambient IGF, leading to phosphatidylinositol 3-kinase/AKT-dependent Wnt/LRP5 r. J Biol Chem. 2010;285:8743-58 pubmed publisher
Roselli F, Hutzler P, Wegerich Y, Livrea P, Almeida O. Disassembly of shank and homer synaptic clusters is driven by soluble beta-amyloid(1-40) through divergent NMDAR-dependent signalling pathways. PLoS ONE. 2009;4:e6011 pubmed publisher
Madhunapantula S, Sharma A, Robertson G. PRAS40 deregulates apoptosis in malignant melanoma. Cancer Res. 2007;67:3626-36 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2151

SKU :

2151/10

product name :

API-2

description :

Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral

target :

Akt (Protein Kinase B) Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

99%

storage :

Store at RT

observed molecular weight :

320.31

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

API-2 is a selective inhibitor of Akt (protein kinase B) signaling; displays minimal inhibition of PKC, PKA, SGK and p38 pathways. Inhibits phosphorylation and activation of downstream targets of Akt including Bad, GSK-3 and AFX. Induces apoptosis and growth arrest in vitro , preferentially in human cancer cells with elevated levels of Akt. Potently and selectively inhibits growth of Akt-overexpressing tumors in mice. Inhibits DNA synthesis and displays antiviral activity against HIV-1 and -2.

product keywords :

Selective inhibitors inhibits Akt PKB signaling Antitumor antiviral Protein Kinase B NSC154020 Triciribine NSC 154020 TCN Akt (Protein Kinase B) Protein Kinase B/Akt HIV 2151,

extended description :

Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral

chemical name text :

1,5-Dihydro-5-methyl-1- -D-ribofuranosyl-1,4,5,6,8-pentaazaacenaphthylen-3-amine

formula :

C13H16N6O4

formula text :

C13H16N6O4

cas num :

35943-35-2

USD :

396

USD 2025 :

400 USD

product details :

Selective inhibitor of Akt/PKB signaling. Antitumor and antiviral

alt names :

Triciribine,NSC 154020,TCN

more info or order :

Tocris Bioscience product webpage