chemical

nTZDpa

2150/10

10 mg (also 50 mg)

231 USD

2150

2150/10

nTZDpa

Potent, selective PPAR partial agonist

PPAR gamma Receptor Agonists

10 mg (also 50 mg)

Small Molecules

98%

Store at +4°C

428.33

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nTZDpa is a potent, selective non-thiazolidinedione PPAR partial agonist (EC50 = 57 nM); produces ~25% maximum efficacy. Antagonizes full agonist activity by ~60% (IC50 ~ 285 nM). Displays no activity at PPAR or PPAR receptors. Produces altered receptor conformation, and regulates adipocyte development and gene expression, in a differential manner to full PPAR agonists. Modulates metabolism and insulin sensitivity without causing cardiac hypertrophy in mice in vivo .

Potent selective PPAR PPARgamma partial agonists Peroxisome Proliferator-activating Receptors PPARgamma Receptors 2150,

Potent, selective PPAR partial agonist

5-Chloro-1-[(4-chlorophenyl)methyl]-3-(phenylthio)-1H-indole-2-carboxylic acid

C22H15Cl2NO2S

C22H15Cl2NO2S

118414-59-8

228

231 USD

Potent, selective PPAR partial agonist