product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
MRS 2578
catalog :
2146
quantity :
10 mg (also 50 mg)
price :
125 USD
more info or order :
citations: 24
Reference
Bian J, Zhang Y, Liu Y, Li Q, Tang H, Liu Q. P2Y6 Receptor-Mediated Spinal Microglial Activation in Neuropathic Pain. Pain Res Manag. 2019;2019:2612534 pubmed publisher
Uderhardt S, Martins A, Tsang J, Lämmermann T, Germain R. Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell. 2019;177:541-555.e17 pubmed publisher
Dosch M, Zindel J, Jebbawi F, Melin N, Sánchez Taltavull D, Stroka D, et al. Connexin-43-dependent ATP release mediates macrophage activation during sepsis. elife. 2019;8: pubmed publisher
Nishimura Y, McLaughlin N, Pan J, Goldstein S, Hafenstein S, Shimizu H, et al. The Suramin Derivative NF449 Interacts with the 5-fold Vertex of the Enterovirus A71 Capsid to Prevent Virus Attachment to PSGL-1 and Heparan Sulfate. PLoS Pathog. 2015;11:e1005184 pubmed publisher
Kawano A, Kadomatsu R, Ono M, Kojima S, Tsukimoto M, Sakamoto H. Autocrine Regulation of UVA-Induced IL-6 Production via Release of ATP and Activation of P2Y Receptors. PLoS ONE. 2015;10:e0127919 pubmed publisher
Obba S, Hizir Z, Boyer L, Selimoglu Buet D, Pfeifer A, Michel G, et al. The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML. Autophagy. 2015;11:1114-29 pubmed publisher
Balasubramanian R, Robaye B, Boeynaems J, Jacobson K. Enhancement of glucose uptake in mouse skeletal muscle cells and adipocytes by P2Y6 receptor agonists. PLoS ONE. 2014;9:e116203 pubmed publisher
Braganhol E, Kukulski F, Lévesque S, Fausther M, Lavoie E, Zanotto Filho A, et al. Nucleotide receptors control IL-8/CXCL8 and MCP-1/CCL2 secretions as well as proliferation in human glioma cells. Biochim Biophys Acta. 2015;1852:120-30 pubmed publisher
Campwala H, Sexton D, Crossman D, Fountain S. P2Y₆ receptor inhibition perturbs CCL2-evoked signalling in human monocytic and peripheral blood mononuclear cells. J Cell Sci. 2014;127:4964-73 pubmed publisher
Quintas C, Pinho D, Pereira C, Saraiva L, Gonçalves J, Queiroz G. Microglia P2Y₆ receptors mediate nitric oxide release and astrocyte apoptosis. J Neuroinflammation. 2014;11:141 pubmed publisher
Barragán Iglesias P, Pineda Farias J, Cervantes Durán C, Bravo Hernández M, Rocha González H, Murbartián J, et al. Role of spinal P2Y6 and P2Y11 receptors in neuropathic pain in rats: possible involvement of glial cells. Mol Pain. 2014;10:29 pubmed publisher
Carneiro I, Timóteo M, Silva I, Vieira C, Baldaia C, Ferreirinha F, et al. Activation of P2Y6 receptors increases the voiding frequency in anaesthetized rats by releasing ATP from the bladder urothelium. Br J Pharmacol. 2014;171:3404-19 pubmed publisher
Alsaqati M, Chan S, Ralevic V. Investigation of the functional expression of purine and pyrimidine receptors in porcine isolated pancreatic arteries. Purinergic Signal. 2014;10:241-9 pubmed publisher
Yu W, Sun X, Robson S, Hill W. Extracellular UDP enhances P2X-mediated bladder smooth muscle contractility via P2Y(6) activation of the phospholipase C/inositol trisphosphate pathway. FASEB J. 2013;27:1895-903 pubmed publisher
Balasubramanian R, Maruoka H, Jayasekara P, Gao Z, Jacobson K. AMP-activated protein kinase as regulator of P2Y(6) receptor-induced insulin secretion in mouse pancreatic β-cells. Biochem Pharmacol. 2013;85:991-8 pubmed publisher
Sivaramakrishnan V, Bidula S, Campwala H, Katikaneni D, Fountain S. Constitutive lysosome exocytosis releases ATP and engages P2Y receptors in human monocytes. J Cell Sci. 2012;125:4567-75 pubmed publisher
Zizzo M, Mastropaolo M, Grählert J, Mulè F, Serio R. Pharmacological characterization of uracil nucleotide-preferring P2Y receptors modulating intestinal motility: a study on mouse ileum. Purinergic Signal. 2012;8:275-85 pubmed publisher
Martín Gil A, de Lara M, Crooke A, Santano C, Peral A, Pintor J. Silencing of P2Y(2) receptors reduces intraocular pressure in New Zealand rabbits. Br J Pharmacol. 2012;165:1163-72 pubmed publisher
Genetos D, Karin N, Geist D, Donahue H, Duncan R. Purinergic signaling is required for fluid shear stress-induced NF-?B translocation in osteoblasts. Exp Cell Res. 2011;317:737-44 pubmed publisher
Riegel A, Faigle M, Zug S, Rosenberger P, Robaye B, Boeynaems J, et al. Selective induction of endothelial P2Y6 nucleotide receptor promotes vascular inflammation. Blood. 2011;117:2548-55 pubmed publisher
Tokunaga A, Tsukimoto M, Harada H, Moriyama Y, Kojima S. Involvement of SLC17A9-dependent vesicular exocytosis in the mechanism of ATP release during T cell activation. J Biol Chem. 2010;285:17406-16 pubmed publisher
Talasila A, Germack R, Dickenson J. Characterization of P2Y receptor subtypes functionally expressed on neonatal rat cardiac myofibroblasts. Br J Pharmacol. 2009;158:339-53 pubmed publisher
Mamedova L, Wang R, Besada P, Liang B, Jacobson K. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacol Res. 2008;58:232-9 pubmed publisher
Kukulski F, Ben Yebdri F, Lefebvre J, Warny M, Tessier P, Sevigny J. Extracellular nucleotides mediate LPS-induced neutrophil migration in vitro and in vivo. J Leukoc Biol. 2007;81:1269-75 pubmed
product information
brand :
Tocris
master code :
2146
SKU :
2146/10
product name :
MRS 2578
description :
Selective P2Y6 antagonist
target :
P2Y Receptor Antagonists
category :
Small Molecules
unit size :
10 mg (also 50 mg)
purity :
95%
observed molecular weight :
472.66
url print :
?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
Selective antagonist of P2Y6 nucleotide receptors; IC50 values are 37 and 98 nM at human and rat P2Y6 receptors respectively. Displays no activity at P2Y1, P2Y2, P2Y4 and P2Y11 receptors (IC50 10 u M). Inhibits agonist-induced cardiomyocyte contraction and UDP-induced phagocytosis.
catalog number base :
2146
product keywords :
Selective P2Y6 antagonists Receptors Purinergic purinoceptors MRS2578 Purinergic P2Y Receptors 2146,
extended description :
Selective P2Y6 antagonist
chemical name text :
N,N -1,4-Butanediylbis[N -(3-isothiocyanatophenyl)thiourea
formula :
C 20 H 20 N 6 S 4
formula text :
C20H20N6S4
cas num :
711019-86-2
2020 USD :
120
2021 USD :
125 USD
storage :
Desiccate at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK