Paroxetine maleate | Tocris Bioscience 2141 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Paroxetine maleate

catalog :

2141

quantity :

10 mg (also 50 mg)

price :

151 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Zhou W, Jin Y, Meng Q, Zhu X, Bai T, Tian Y, et al. A neural circuit for comorbid depressive symptoms in chronic pain. Nat Neurosci. 2019;22:1649-1658 pubmed publisher
Lazar A, Lenkey N, Pesti K, Fodor L, Mike A. Different pH-sensitivity patterns of 30 sodium channel inhibitors suggest chemically different pools along the access pathway. Front Pharmacol. 2015;6:210 pubmed publisher
Steiner J, Bachani M, Wolfson Stofko B, Lee M, Wang T, Wang T, et al. Interaction of paroxetine with mitochondrial proteins mediates neuroprotection. Neurotherapeutics. 2015;12:200-16 pubmed publisher
Mathes C, Spector A. Systemic modulation of serotonergic synapses via reuptake blockade or 5HT1A receptor antagonism does not alter perithreshold taste sensitivity in rats. Chem Senses. 2014;39:583-93 pubmed publisher
Mathes C, Gregson J, Spector A. The selective serotonin reuptake inhibitor paroxetine decreases breakpoint of rats engaging in a progressive ratio licking task for sucrose and quinine solutions. Chem Senses. 2013;38:211-20 pubmed publisher
Mathes C, Spector A. The selective serotonin reuptake inhibitor paroxetine does not alter consummatory concentration-dependent licking of prototypical taste stimuli by rats. Chem Senses. 2011;36:515-26 pubmed publisher
Huang Y, Dando R, Roper S. Autocrine and paracrine roles for ATP and serotonin in mouse taste buds. J Neurosci. 2009;29:13909-18 pubmed publisher

product information

brand :

Tocris

master code :

2141

SKU :

2141/10

product name :

Paroxetine maleate

description :

Highly potent and selective 5-HT uptake inhibitor

target :

5-HT Transporter Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

445.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter (Ki = 0.05 nM). Ki values are 1.1, 350 and 1100 nM for inhibition of [3H]-5-HT, [3H]-l-NA and [3H]-DA uptake respectively. Displays minimal affinity for 1-, 2- or -adrenoceptors, 5-HT2A, 5-HT1A, D2 or H1 receptors at concentrations below 1000 nM, however displays weak affinity for muscarinic ACh receptors (Ki = 42 nM). Antidepressant and anxiolytic in vivo .

catalog number base :

2141

product keywords :

potent selective 5-HT reuptake inhibitors inhibits serotonin inhibitor transporters SERT 5-Hydroxytryptamine monoamine neurotransmitter 5-HT Transporters 2141,

extended description :

Highly potent and selective 5-HT uptake inhibitor

chemical name text :

(3S,4R)-3-[(1,3-Benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine maleate

formula :

C 19 H 20 FNO 3 .C 4 H 4 O 4

formula text :

C19H20FNO3.C4H4O4

cas num :

64006-44-6

2020 USD :

145

2021 USD :

151 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage