This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Tocris Bioscience
product type :
chemical
product name :
alpha-Bungarotoxin
catalog :
2133/1
quantity :
1 mg
price :
237 USD
citations: 28
Reference
Noviello C, Gharpure A, Mukhtasimova N, Cabuco R, Baxter L, Borek D, et al. Structure and gating mechanism of the α7 nicotinic acetylcholine receptor. Cell. 2021;184:2121-2134.e13 pubmed publisher
Zhang R, DU W, Prober D, Du J. Müller Glial Cells Participate in Retinal Waves via Glutamate Transporters and AMPA Receptors. Cell Rep. 2019;27:2871-2880.e2 pubmed publisher
Cao M, MacDonald J, Liu H, Weaver M, Cortes M, Durosier L, et al. α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin. Front Immunol. 2019;10:1063 pubmed publisher
Durham E, Howie R, Warren G, LaRue A, Cray J. Direct Effects of Nicotine Exposure on Murine Calvaria and Calvarial Cells. Sci Rep. 2019;9:3805 pubmed publisher
Zimmermann M, Nevala N, Yoshimatsu T, Osorio D, Nilsson D, Berens P, et al. Zebrafish Differentially Process Color across Visual Space to Match Natural Scenes. Curr Biol. 2018;28:2018-2032.e5 pubmed publisher
Morris M, Shaw A, Lambert M, Perry H, Lowenstein E, Valenzuela D, et al. Developmental nicotine exposure affects larval brain size and the adult dopaminergic system of Drosophila melanogaster. BMC Dev Biol. 2018;18:13 pubmed publisher
Cortes M, Cao M, Liu H, Moore C, Durosier L, Burns P, et al. α7 nicotinic acetylcholine receptor signaling modulates the inflammatory phenotype of fetal brain microglia: first evidence of interference by iron homeostasis. Sci Rep. 2017;7:10645 pubmed publisher
Miyamoto T, Kim D, Knox J, Johnson E, Mucke L. Increasing the Receptor Tyrosine Kinase EphB2 Prevents Amyloid-β-induced Depletion of Cell Surface Glutamate Receptors by a Mechanism That Requires the PDZ-binding Motif of EphB2 and Neuronal Activity. J Biol Chem. 2016;291:1719-34 pubmed publisher
Singh C, Oikonomou G, Prober D. Norepinephrine is required to promote wakefulness and for hypocretin-induced arousal in zebrafish. elife. 2015;4:e07000 pubmed publisher
Bader S, Diener M. Novel aspects of cholinergic regulation of colonic ion transport. Pharmacol Res Perspect. 2015;3:e00139 pubmed publisher
Li W. Selective Gating of Neuronal Activity by Intrinsic Properties in Distinct Motor Rhythms. J Neurosci. 2015;35:9799-810 pubmed publisher
Chatzidaki A, D Oyley J, Gill Thind J, Sheppard T, Millar N. The influence of allosteric modulators and transmembrane mutations on desensitisation and activation of α7 nicotinic acetylcholine receptors. Neuropharmacology. 2015;97:75-85 pubmed publisher
Spurny R, Debaveye S, Farinha A, Veys K, Vos A, Gossas T, et al. Molecular blueprint of allosteric binding sites in a homologue of the agonist-binding domain of the α7 nicotinic acetylcholine receptor. Proc Natl Acad Sci U S A. 2015;112:E2543-52 pubmed publisher
Bryant A, Goddard C, Huguenard J, Knudsen E. Cholinergic control of gamma power in the midbrain spatial attention network. J Neurosci. 2015;35:761-75 pubmed publisher
Gill Thind J, Dhankher P, D Oyley J, Sheppard T, Millar N. Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects. J Biol Chem. 2015;290:3552-62 pubmed publisher
Macpherson A, Zoheir N, Awang R, Culshaw S, Ramage G, Lappin D, et al. The alpha 7 nicotinic receptor agonist PHA-543613 hydrochloride inhibits Porphyromonas gingivalis-induced expression of interleukin-8 by oral keratinocytes. Inflamm Res. 2014;63:557-68 pubmed publisher
Mauss A, Meier M, Serbe E, Borst A. Optogenetic and pharmacologic dissection of feedforward inhibition in Drosophila motion vision. J Neurosci. 2014;34:2254-63 pubmed publisher
Slimak M, Ables J, Frahm S, Antolin Fontes B, Santos Torres J, Moretti M, et al. Habenular expression of rare missense variants of the ?4 nicotinic receptor subunit alters nicotine consumption. Front Hum Neurosci. 2014;8:12 pubmed publisher
Zhong C, Talmage D, Role L. Nicotine elicits prolonged calcium signaling along ventral hippocampal axons. PLoS ONE. 2013;8:e82719 pubmed publisher
Nemethova A, Michel K, Gomez Pinilla P, Boeckxstaens G, Schemann M. Nicotine attenuates activation of tissue resident macrophages in the mouse stomach through the ?2 nicotinic acetylcholine receptor. PLoS ONE. 2013;8:e79264 pubmed publisher
Garção P, Szabó E, Wopereis S, Castro A, Tome A, Prediger R, et al. Functional interaction between pre-synaptic ?6?2-containing nicotinic and adenosine A2A receptors in the control of dopamine release in the rat striatum. Br J Pharmacol. 2013;169:1600-11 pubmed publisher
Kamynina A, Holmström K, Koroev D, Volpina O, Abramov A. Acetylcholine and antibodies against the acetylcholine receptor protect neurons and astrocytes against beta-amyloid toxicity. Int J Biochem Cell Biol. 2013;45:899-907 pubmed publisher
Moult P, Cottrell G, Li W. Fast silencing reveals a lost role for reciprocal inhibition in locomotion. Neuron. 2013;77:129-40 pubmed publisher
Sala M, Braida D, Pucci L, Manfredi I, Marks M, Wageman C, et al. CC4, a dimer of cytisine, is a selective partial agonist at ?4?2/?6?2 nAChR with improved selectivity for tobacco smoking cessation. Br J Pharmacol. 2013;168:835-49 pubmed publisher
Zhu H, Bhattacharyya B, Lin H, Gomez C. Skeletal muscle IP3R1 receptors amplify physiological and pathological synaptic calcium signals. J Neurosci. 2011;31:15269-83 pubmed publisher
Krais A, Hautefeuille A, Cros M, Krutovskikh V, Tournier J, Birembaut P, et al. CHRNA5 as negative regulator of nicotine signaling in normal and cancer bronchial cells: effects on motility, migration and p63 expression. Carcinogenesis. 2011;32:1388-95 pubmed publisher
Demarque M, Spitzer N. Activity-dependent expression of Lmx1b regulates specification of serotonergic neurons modulating swimming behavior. Neuron. 2010;67:321-34 pubmed publisher
Sun X, Ritzenthaler J, Zheng Y, Roman J, Han S. Rosiglitazone inhibits alpha4 nicotinic acetylcholine receptor expression in human lung carcinoma cells through peroxisome proliferator-activated receptor gamma-independent signals. Mol Cancer Ther. 2009;8:110-8 pubmed publisher
product information
brand :
Tocris
master code :
2133
SKU :
2133/1
product name :
alpha-Bungarotoxin
description :
Selective 7 nAChR antagonist
target :
Nicotinic (a7) Receptor Antagonists
category :
Peptides
sizes available :
1 mg
observed molecular weight :
7984.14
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides
details of functionality :
-Bungarotoxin is a neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for 7 receptors over 3 4 receptors (IC50 values are 1.6 nM and 3 u M respectively).
extended description :
Selective 7 nAChR antagonist
formula :
C 338 H 529 N 97 O 105 S 11
formula text :
C338H529N97O105S11
cas num :
11032-79-4
USD :
206
USD 2023 :
237 USD
product details :
Selective 7 nAChR antagonist
alt names :
-Bgtx, -BuTX
storage :
Store at -20°C
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK