Apoptosis Activator 2 | Tocris Bioscience 2098/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Apoptosis Activator 2

catalog :

2098/10

quantity :

10 mg (also 50 mg)

price :

159 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Pan H, Guan D, Liu X, Li J, Wang L, Wu J, et al. SIRT6 safeguards human mesenchymal stem cells from oxidative stress by coactivating NRF2. Cell Res. 2016;26:190-205 pubmed publisher
Stankiewicz A, Lachapelle G, Foo C, Radicioni S, Mosser D. Hsp70 inhibits heat-induced apoptosis upstream of mitochondria by preventing Bax translocation. J Biol Chem. 2005;280:38729-39 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2098

SKU :

2098/10

product name :

Apoptosis Activator 2

description :

Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

target :

Apoptosis Inducer Compounds

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at RT

observed molecular weight :

306.14

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Apoptosis Activator 2 is an apoptosis activator; promotes the cytochrome c-dependent oligomerization of Apaf-1 into the mature apoptosome. Increases procaspase-9 processing and subsequent caspase-3 activation. Induces apoptosis in tumor cells (IC50 = 4 - 9 u M for leukemia cells) with weak or no effect on normal cell lines or those defective/deficient in Apaf-1, caspase-9 or caspase-3 activity (IC50 40 u M).

product keywords :

Promotes apoptosome formation activates caspase-9/caspase-3 pathway induces apoptosis Selective Inducer Apoptosis Activator2 Caspases Apoptosis Inducers 2098,

extended description :

Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

chemical name text :

1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione

formula :

C15H9Cl2NO2

formula text :

C15H9Cl2NO2

cas num :

79183-19-0

USD :

176

USD 2025 :

159 USD

product details :

Promotes apoptosome formation and activates caspase-9/caspase-3 pathway. Selectively induces tumor cell apoptosis

more info or order :

Tocris Bioscience product webpage