SKI II | Tocris Bioscience 2097 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SKI II

catalog :

2097

quantity :

10 mg (also 50 mg)

price :

170 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Seong B, Fathers K, Hallett R, Yung C, Stein L, Mouaaz S, et al. A Metastatic Mouse Model Identifies Genes That Regulate Neuroblastoma Metastasis. Cancer Res. 2017;77:696-706 pubmed publisher
Reid S, Tritsch S, Kota K, Chiang C, Dong L, Kenny T, et al. Sphingosine kinase 2 is a chikungunya virus host factor co-localized with the viral replication complex. Emerg Microbes Infect. 2015;4:e61 pubmed publisher
Xun C, Chen M, Qi L, Tie Ning Z, Peng X, Ning L, et al. Targeting sphingosine kinase 2 (SphK2) by ABC294640 inhibits colorectal cancer cell growth in vitro and in vivo. J Exp Clin Cancer Res. 2015;34:94 pubmed publisher
Minashima T, Campbell K, Hadley S, Zhang Y, Kirsch T. The role of ANK interactions with MYBBP1a and SPHK1 in catabolic events of articular chondrocytes. Osteoarthritis Cartilage. 2014;22:852-61 pubmed publisher
Park S, Kim J, Ham A, Brown K, Kim M, D Agati V, et al. A1 adenosine receptor allosteric enhancer PD-81723 protects against renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2012;303:F721-32 pubmed publisher
Kim M, Kim M, Park S, Pitson S, Lee H. Isoflurane protects human kidney proximal tubule cells against necrosis via sphingosine kinase and sphingosine-1-phosphate generation. Am J Nephrol. 2010;31:353-62 pubmed publisher

product information

brand :

Tocris

master code :

2097

SKU :

2097/10

product name :

SKI II

description :

Selective non-lipid inhibitor of sphingosine kinase

target :

Sphingosine Kinase Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

302.78

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 u M); does not act at ATP-binding site. Displays no inhibition of ERK2, PI 3-kinase, or PKC at concentrations up to 60 u M. Reduces levels of sphingosine-1-phosphate in MDA-MB-231 breast cancer cells. Induces apoptosis and inhibits proliferation in several other tumor cell lines in vitro (IC50 = 0.9 - 4.6 u M).

catalog number base :

2097

product keywords :

Selective non-lipid inhibitors inhibits sphingosine kinases antitumor Lipid Metabolism sphingosine-1-phosphate S1P SKIII sphk Sphingosine Kinase 2097,

extended description :

Selective non-lipid inhibitor of sphingosine kinase

chemical name text :

4-[[4-(4-Chlorophenyl)-2-thiazolyl]amino]phenol

formula :

C 15 H 11 ClN 2 OS

formula text :

C15H11ClN2OS

cas num :

312636-16-1

2020 USD :

166

2021 USD :

170 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage