RS 102895 hydrochloride | Tocris Bioscience 2089 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

RS 102895 hydrochloride

catalog :

2089

quantity :

10 mg (also 50 mg)

price :

162 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Teng K, Han J, Zhang X, Hsu S, He S, Wani N, et al. Blocking the CCL2-CCR2 Axis Using CCL2-Neutralizing Antibody Is an Effective Therapy for Hepatocellular Cancer in a Mouse Model. Mol Cancer Ther. 2017;16:312-322 pubmed publisher
Cerri C, Genovesi S, Allegra M, Pistillo F, Püntener U, Guglielmotti A, et al. The Chemokine CCL2 Mediates the Seizure-enhancing Effects of Systemic Inflammation. J Neurosci. 2016;36:3777-88 pubmed publisher
Maxwell P, Neisen J, Messenger J, Waugh D. Tumor-derived CXCL8 signaling augments stroma-derived CCL2-promoted proliferation and CXCL12-mediated invasion of PTEN-deficient prostate cancer cells. Oncotarget. 2014;5:4895-908 pubmed
Sennlaub F, Auvynet C, Calippe B, Lavalette S, Poupel L, Hu S, et al. CCR2(+) monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice. EMBO Mol Med. 2013;5:1775-93 pubmed publisher
Hung Y, Lai M, Tseng Y, Chou C, Lin Y. Monocyte chemoattractant protein-1 affects migration of hippocampal neural progenitors following status epilepticus in rats. J Neuroinflammation. 2013;10:11 pubmed publisher

product information

brand :

Tocris

master code :

2089

SKU :

2089/10

product name :

RS 102895 hydrochloride

description :

CCR2b chemokine receptor antagonist

target :

Chemokine Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

426.86

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

CCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 u M for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 u M respectively. Also inhibits 1A, 1D and 5-HT1A receptors.

catalog number base :

2089

product keywords :

CCR2b chemokine receptor antagonists Chemokine Receptors RS102895 hydrochloride Chemokine CC Receptors 2089,

extended description :

CCR2b chemokine receptor antagonist

chemical name text :

1 -[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4 -piperidin]-2(1H)-one hydrochloride

formula :

C 21 H 21 F 3 N 2 O 2 .HCl

formula text :

C21H21F3N2O2.HCl

cas num :

1173022-16-6

2020 USD :

155

2021 USD :

162 USD

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage