UBP 302 | Tocris Bioscience 2079/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

UBP 302

catalog :

2079/10

quantity :

10 mg (also 50 mg)

price :

367 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Caiati M, Safiulina V, Fattorini G, Sivakumaran S, Legname G, Cherubini E. PrPC controls via protein kinase A the direction of synaptic plasticity in the immature hippocampus. J Neurosci. 2013;33:2973-83 pubmed publisher
Randall F, Whittington M, Cunningham M. Fast oscillatory activity induced by kainate receptor activation in the rat basolateral amygdala in vitro. Eur J Neurosci. 2011;33:914-22 pubmed publisher
Talpalar A, Kiehn O. Glutamatergic mechanisms for speed control and network operation in the rodent locomotor CpG. Front Neural Circuits. 2010;4: pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2079

SKU :

2079/10

product name :

UBP 302

description :

Potent and selective kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)

target :

Kainate Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

333.3

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

UBP 302 is a potent and selective GluK1 (formally GluR5)-subunit containing kainate receptor antagonist (apparent KD = 402 nM); active enantiomer of UBP 296 (Cat. No. 2078). Displays ~ 260-fold selectivity over AMPA receptors, ~ 90-fold selectivity over recombinant human GluK2 (formally GluR6) and GluK5 (formally KA2)-containing kainate receptors and has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. Also protects against soman-induced seizures and neuronal degeneration for up to 30 days when administered one hour after soman exposure. Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

product keywords :

Selective potent kainate antagonists Glutamate Kainate Receptors iGluR Ionotropic UBP302 neurodegeneration Kainate Receptors 2079,

extended description :

Potent and selective kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)

chemical name text :

(S)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione

formula :

C15H15N3O6

formula text :

C15H15N3O6

cas num :

745055-91-8

USD :

363

USD 2025 :

367 USD

product details :

Potent and selective kainate antagonist; active enantiomer of UBP 296 (Cat. No. 2078)

more info or order :

Tocris Bioscience product webpage