UBP 296 | Tocris Bioscience 2078/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

UBP 296

catalog :

2078/10

quantity :

10 mg (also 50 mg)

price :

261 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
AlbiÃ±ana E, Gutierrez Luengo J, HernÃ¡ndez Juarez N, Baraibar A, Montell E, VergÃ©s J, et al. Chondroitin Sulfate Induces Depression of Synaptic Transmission and Modulation of Neuronal Plasticity in Rat Hippocampal Slices. Neural Plast. 2015;2015:463854 pubmed publisher

product information

brand :

Tocris

catalog number base :

2078

SKU :

2078/10

product name :

UBP 296

units size :

10 mg (also 50 mg)

description :

Potent and selective kainate antagonist; selective for GluK1-containing receptors

target :

Kainate Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

333.3

url print :

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details of functionality :

UBP 296 is a selective GluK1 (formally GluR5) subunit containing kainate receptor antagonist (apparent KD = 1.09 M). Displays ~ 90-fold selectivity over AMPA receptors and recombinant hGluK2 (formally hGluR6) and GluK5 (formally KA2) containing kainate receptors. Has little or no action at NMDA or group I mGlu receptors. Selectively blocks kainate receptor-mediated LTP induction in rat hippocampal mossy fibers. . Active Enantiomer also available. . Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions .

top caption :

Potent and selective kainate antagonist; selective for GluK1-containing receptors

extended description :

Potent and selective kainate antagonist; selective for GluK1-containing receptors

chemical name text :

(RS)-1-(2-Amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione

formula :

C15H15N3O6

formula text :

C15H15N3O6

cas num :

745055-86-1

USD :

261 USD

product details :

Potent and selective kainate antagonist; selective for GluK1-containing receptors

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage