SKF 83822 hydrobromide | Tocris Bioscience 2075 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SKF 83822 hydrobromide

catalog :

2075

quantity :

10 mg (also 50 mg)

price :

208 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Kramar C, Chefer V, Wise R, Medina J, Barbano M. Dopamine in the dorsal hippocampus impairs the late consolidation of cocaine-associated memory. Neuropsychopharmacology. 2014;39:1645-53 pubmed publisher
Ruskin D, Svedova J, Cote J, SANDAU U, Rho J, Kawamura M, et al. Ketogenic diet improves core symptoms of autism in BTBR mice. PLoS ONE. 2013;8:e65021 pubmed publisher
Urizar E, Yano H, Kolster R, Gales C, Lambert N, Javitch J. CODA-RET reveals functional selectivity as a result of GPCR heteromerization. Nat Chem Biol. 2011;7:624-30 pubmed publisher

product information

brand :

Tocris

master code :

2075

SKU :

2075/10

product name :

SKF 83822 hydrobromide

description :

Selective D1-like agonist

target :

Dopamine D1 and D5 Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

424.76

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

High affinity, selective dopamine D1-like receptor agonist. Ki values are 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, 1A and 1B receptors respectively. Stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Induces extreme arousal and hyperlocomotion following subcutaneous administration in monkeys.

catalog number base :

2075

product keywords :

Selective D1-like agonists Dopamine D1 Receptors D5 dopaminergic SKF83822 hydrobromide D1 and D5 Receptors 2075,

extended description :

Selective D1-like agonist

chemical name text :

6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide

formula :

C 20 H 22 ClNO 2 .HBr

formula text :

C20H22ClNO2.HBr

cas num :

74115-10-9

2020 USD :

201

2021 USD :

208 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage