SKF 83959 hydrobromide | Tocris Bioscience 2074 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SKF 83959 hydrobromide

catalog :

2074

quantity :

10 mg (also 50 mg)

price :

208 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
Perreault M, Shen M, Fan T, George S. Regulation of c-fos expression by the dopamine D1-D2 receptor heteromer. Neuroscience. 2015;285:194-203 pubmed publisher
Shen M, Perreault M, Fan T, George S. The dopamine D1-D2 receptor heteromer exerts a tonic inhibitory effect on the expression of amphetamine-induced locomotor sensitization. Pharmacol Biochem Behav. 2015;128:33-40 pubmed publisher
Cassar M, Issa A, Riemensperger T, Petitgas C, Rival T, Coulom H, et al. A dopamine receptor contributes to paraquat-induced neurotoxicity in Drosophila. Hum Mol Genet. 2015;24:197-212 pubmed publisher
Fuenzalida J, Galaz P, Araya K, Slater P, Blanco E, Campusano J, et al. Dopamine D1 and corticotrophin-releasing hormone type-2? receptors assemble into functionally interacting complexes in living cells. Br J Pharmacol. 2014;171:5650-64 pubmed publisher
Huang C, Wu J, Liao R, Zhang W. SKF83959, an agonist of phosphatidylinositol-linked D(1)-like receptors, promotes ERK1/2 activation and cell migration in cultured rat astrocytes. PLoS ONE. 2012;7:e49954 pubmed publisher
Perreault M, Jones Tabah J, O Dowd B, George S. A physiological role for the dopamine D5 receptor as a regulator of BDNF and Akt signalling in rodent prefrontal cortex. Int J Neuropsychopharmacol. 2013;16:477-83 pubmed publisher

product information

brand :

Tocris

master code :

2074

SKU :

2074/10

product name :

SKF 83959 hydrobromide

description :

D1-like partial agonist

target :

Dopamine D1 and D5 Receptor Agonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

398.73

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Dopamine D1-like receptor partial agonist (Ki values are 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors respectively). May act as an antagonist in vivo , producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. Shown to potentiate agonist binding of the 1 receptor.

catalog number base :

2074

product keywords :

D1-like partial agonists Dopamine D1 Receptors D5 dopaminergic SKF83959 hydrobromide D1 and D5 Receptors Sigma1 Receptors 2074,

extended description :

D1-like partial agonist

chemical name text :

6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol

formula :

C 18 H 20 ClNO 2 .HBr

formula text :

C18H20ClNO2.HBr

cas num :

67287-95-0

2020 USD :

201

2021 USD :

208 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage