LE 135 | Tocris Bioscience 2021 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

LE 135

catalog :

2021

quantity :

10 mg (also 50 mg)

price :

171 USD

more info or order :

Tocris Bioscience product webpage

citations: 17

Reference
Bi W, Liu Y, Guo J, Lin Z, Liu J, Zhou M, et al. All-trans retinoic-acid inhibits heterodimeric bone morphogenetic protein 2/7-stimulated osteoclastogenesis, and resorption activity. Cell Biosci. 2018;8:48 pubmed publisher
Metzler M, Raja S, Elliott K, Friedl R, Tran N, Brugmann S, et al. RDH10-mediated retinol metabolism and RARα-mediated retinoic acid signaling are required for submandibular salivary gland initiation. Development. 2018;145: pubmed publisher
Nguyen M, Singhal P, Piet J, Shefelbine S, Maden M, Voss S, et al. Retinoic acid receptor regulation of epimorphic and homeostatic regeneration in the axolotl. Development. 2017;144:601-611 pubmed publisher
Duprey Díaz M, Blagburn J, Blanco R. Exogenous Modulation of Retinoic Acid Signaling Affects Adult RGC Survival in the Frog Visual System after Optic Nerve Injury. PLoS ONE. 2016;11:e0162626 pubmed publisher
Gao Z, Huo L, Cui D, Yang X, Zeng J. The Expression of Bone Morphogenetic Protein 2 and Matrix Metalloproteinase 2 through Retinoic Acid Receptor Beta Induced by All-Trans Retinoic Acid in Cultured ARPE-19 Cells. PLoS ONE. 2016;11:e0150831 pubmed publisher
Chen H, Sun A, Ojcius D, Hu W, Ge Y, Lin X, et al. Eosinophils from Murine Lamina Propria Induce Differentiation of NaÃ¯ve T Cells into Regulatory T Cells via TGF-Î²1 and Retinoic Acid. PLoS ONE. 2015;10:e0142881 pubmed publisher
MÃ¼ller P, Doliva R, Busch M, Philippeit C, Stephan H, DÃ¼nker N. Additive Effects of Retinoic Acid (RA) and Bone Morphogenetic Protein 4 (BMP-4) Apoptosis Signaling in Retinoblastoma Cell Lines. PLoS ONE. 2015;10:e0131467 pubmed publisher
Bhatt S, Qin J, Bennett C, Qian S, Fung J, Hamilton T, et al. All-trans retinoic acid induces arginase-1 and inducible nitric oxide synthase-producing dendritic cells with T cell inhibitory function. J Immunol. 2014;192:5098-108 pubmed publisher
Thomas A, Henry J. Retinoic acid regulation by CYP26 in vertebrate lens regeneration. Dev Biol. 2014;386:291-301 pubmed publisher
Gloudemans A, Plantinga M, Guilliams M, Willart M, Ozir Fazalalikhan A, van der Ham A, et al. The mucosal adjuvant cholera toxin B instructs non-mucosal dendritic cells to promote IgA production via retinoic acid and TGF-β. PLoS ONE. 2013;8:e59822 pubmed publisher
Cruz D, Koishi A, Taniguchi J, Li X, Milan Bonotto R, No J, et al. High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses. PLoS Negl Trop Dis. 2013;7:e2073 pubmed publisher
Mizee M, Wooldrik D, Lakeman K, Van het Hof B, Drexhage J, Geerts D, et al. Retinoic acid induces blood-brain barrier development. J Neurosci. 2013;33:1660-71 pubmed publisher
Dhandapani L, Yue P, Ramalingam S, Khuri F, Sun S. Retinoic acid enhances TRAIL-induced apoptosis in cancer cells by upregulating TRAIL receptor 1 expression. Cancer Res. 2011;71:5245-54 pubmed publisher
Depaolo R, Abadie V, Tang F, Fehlner Peach H, Hall J, Wang W, et al. Co-adjuvant effects of retinoic acid and IL-15 induce inflammatory immunity to dietary antigens. Nature. 2011;471:220-4 pubmed publisher
Feng T, Cong Y, Qin H, Benveniste E, Elson C. Generation of mucosal dendritic cells from bone marrow reveals a critical role of retinoic acid. J Immunol. 2010;185:5915-25 pubmed publisher
Borel V, Marceau G, Gallot D, Blanchon L, Sapin V. Retinoids regulate human amniotic tissue-type plasminogen activator gene by a two-step mechanism. J Cell Mol Med. 2010;14:1793-805 pubmed publisher
Sun C, Hall J, Blank R, Bouladoux N, Oukka M, Mora J, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med. 2007;204:1775-85 pubmed

product information

brand :

Tocris

master code :

2021

SKU :

2021/10

product name :

LE 135

description :

Selective RAR antagonist

target :

Retinoic Acid Receptor Antagonists

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

97%

observed molecular weight :

438.56

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Retinoic acid antagonist; displays moderate selectivity for RAR over RAR (Ki values are 0.22 and 1.4 u M respectively). Highly selective over RAR and RXR . Inhibits human HL-60 leukemia cell differentiation induced by Am80 (IC50 = 150 nM).

catalog number base :

2021

product keywords :

Selective RAR RARbeta antagonists RAMBA Retinoic Acid Receptors LE135 Retinoic Acid Receptors 2021,

extended description :

Selective RAR antagonist

chemical name text :

4-(7,8,9,10-Tetrahydro-5,7,7,10,10-pentamethyl-5H-benzo[e]naphtho[2,3-b][1,4]diazepin-13-yl)benzoic acid

formula :

C 29 H 30 N 2 O 2

formula text :

C29H30N2O2

cas num :

155877-83-1

2020 USD :

164

2021 USD :

171 USD

storage :

Store at +4°C

more info or order :

Tocris Bioscience product webpage