Ch 55 | Tocris Bioscience 2020/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ch 55

catalog :

2020/10

quantity :

10 mg (also 50 mg)

price :

220 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Li X, Liu D, Ma Y, Du X, Jing J, Wang L, et al. Direct Reprogramming of Fibroblasts via a Chemically Induced XEN-like State. Cell Stem Cell. 2017;21:264-273.e7 pubmed publisher
Dhandapani L, Yue P, Ramalingam S, Khuri F, Sun S. Retinoic acid enhances TRAIL-induced apoptosis in cancer cells by upregulating TRAIL receptor 1 expression. Cancer Res. 2011;71:5245-54 pubmed publisher

product information

brand :

Tocris

catalog number base :

2020

SKU :

2020/10

product name :

Ch 55

units size :

10 mg (also 50 mg)

description :

Potent RAR agonist

target :

Retinoic Acid Receptor Agonists

category :

Small Molecules

purity :

98%

observed molecular weight :

364.47

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

review stars :

details of functionality :

Ch 55 is a highly potent synthetic retinoid that has high affinity for RAR- and RAR- receptors and low affinity for cellular retinoic acid binding protein (CRABP). Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC50 values are 0.02 and 0.03 nM respectively). Induces differentiation of embryonic carcinoma F9 and melanoma S91 cells (EC50 values are 0.26 and 0.5 nM respectively) and inhibits the induction of ornithine decarboxylase activity in 3T6 fibroblasts (EC50 = 1 nM). Enables generation of Chemically Induced Pluripotent Stem Cells (CiPSCs) from mouse embryonic fibroblasts (MEFs) (see our protocol below). . For more information about how Ch 55 may be used, see our protocol: Highly Efficient Generation of CiPSCs from MEFs

top caption :

Potent RAR agonist

extended description :

Potent RAR agonist

chemical name text :

4-[(1E)-3-[3,5-bis(1,1-Dimethylethyl)phenyl]-3-oxo-1-propenyl]benzoic acid

formula :

C24H28O3

formula text :

C24H28O3

cas num :

110368-33-7

USD :

220 USD

product details :

Potent RAR agonist

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage