PSB 10 hydrochloride | Tocris Bioscience 2010/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PSB 10 hydrochloride

catalog :

2010/10

quantity :

10 mg (also 50 mg)

price :

267 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Jeon J, Bersini S, Gilardi M, Dubini G, Charest J, Moretti M, et al. Human 3D vascularized organotypic microfluidic assays to study breast cancer cell extravasation. Proc Natl Acad Sci U S A. 2015;112:214-9 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2010

SKU :

2010/10

product name :

PSB 10 hydrochloride

description :

Potent, highly selective hA3 receptor antagonist/inverse agonist

target :

Adenosine A3 Receptor Antagonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Desiccate at +4°C

observed molecular weight :

435.14

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PSB 10 hydrochloride is a potent and highly selective antagonist for the human adenosine A3 receptor, with low affinity for the rat A3 receptor (Ki values are 0.44 and 17000 nM respectively). Displays 3800-fold selectivity over human A1, A2A and A2B receptors (Ki values are 4.1, 3.3 and 30 u M respectively) and 1800-fold selectivity over rat A1 and A2A receptors. Acts as an inverse agonist in the [35S]GTP S binding assay in hA3-CHO cells (IC50 = 4 nM). Produces thermal hyperalgesia in mice in vivo .

product keywords :

Potent selective human A3 receptors antagonists inverse agonists adenosines PSB10 hydrochloride HCl Adenosine A3 Receptors 2010,

extended description :

Potent, highly selective hA3 receptor antagonist/inverse agonist

chemical name text :

(8R)-8-Ethyl-1,4,7,8-tetrahydro-4-methyl-2-(2,3,5-trichlorophenyl)-5H-imidazo[2,1-i]purin-5-one monohydrochloride

formula :

C16H14Cl3N5O.HCl

formula text :

C16H14Cl3N5O.HCl

cas num :

591771-91-4

USD :

264

USD 2025 :

267 USD

product details :

Potent, highly selective hA3 receptor antagonist/inverse agonist

more info or order :

Tocris Bioscience product webpage