PSB 1115 | Tocris Bioscience 2009/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

PSB 1115

catalog :

2009/10

quantity :

10 mg (also 50 mg)

price :

218 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Zhang Y, Chen P, Di G, Qi X, Zhou Q, Gao H. Netrin-1 promotes diabetic corneal wound healing through molecular mechanisms mediated via the adenosine 2B receptor. Sci Rep. 2018;8:5994 pubmed publisher
Sassi Y, Ahles A, Truong D, Baqi Y, Lee S, Husse B, et al. Cardiac myocyte-secreted cAMP exerts paracrine action via adenosine receptor activation. J Clin Invest. 2014;124:5385-97 pubmed publisher
Ning C, Wen J, Zhang Y, Dai Y, Wang W, Zhang W, et al. Excess adenosine A2B receptor signaling contributes to priapism through HIF-1? mediated reduction of PDE5 gene expression. FASEB J. 2014;28:2725-35 pubmed publisher
Rao S, Tortola L, Perlot T, Wirnsberger G, Novatchkova M, Nitsch R, et al. A dual role for autophagy in a murine model of lung cancer. Nat Commun. 2014;5:3056 pubmed publisher
Iannone R, Miele L, Maiolino P, Pinto A, Morello S. Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma. Neoplasia. 2013;15:1400-9 pubmed
Chia J, McRae J, Thomas H, Fynch S, Elkerbout L, Hill P, et al. The protective effects of CD39 overexpression in multiple low-dose streptozotocin-induced diabetes in mice. Diabetes. 2013;62:2026-35 pubmed publisher
Warren C, Li Y, Calabrese G, Freire R, Zaja Milatovic S, van Opstal E, et al. Contribution of adenosine A(2B) receptors in Clostridium difficile intoxication and infection. Infect Immun. 2012;80:4463-73 pubmed publisher
Hua X, Chason K, Patel J, Naselsky W, Tilley S. IL-4 amplifies the pro-inflammatory effect of adenosine in human mast cells by changing expression levels of adenosine receptors. PLoS ONE. 2011;6:e24947 pubmed publisher
Stagg J, Divisekera U, McLaughlin N, Sharkey J, Pommey S, Denoyer D, et al. Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc Natl Acad Sci U S A. 2010;107:1547-52 pubmed publisher
Frick J, MacManus C, Scully M, Glover L, Eltzschig H, Colgan S. Contribution of adenosine A2B receptors to inflammatory parameters of experimental colitis. J Immunol. 2009;182:4957-64 pubmed publisher
Hart M, Jacobi B, Schittenhelm J, Henn M, Eltzschig H. Cutting Edge: A2B Adenosine receptor signaling provides potent protection during intestinal ischemia/reperfusion injury. J Immunol. 2009;182:3965-8 pubmed publisher
Eckle T, Grenz A, Laucher S, Eltzschig H. A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice. J Clin Invest. 2008;118:3301-15 pubmed publisher

product information

brand :

Tocris

catalog number base :

2009

SKU :

2009/10

product name :

PSB 1115

units size :

10 mg (also 50 mg)

description :

Selective human A2B antagonist; water-soluble

target :

Adenosine A2b Receptor Antagonists

category :

Small Molecules

purity :

98%

observed molecular weight :

350.35

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

PSB 1115 is a highly selective, water-soluble, human A2B adenosine receptor antagonist. Ki values are 53.4, 10000 and 10000 nM at human A2B, A1 and A3 receptors respectively. Also selective versus rat A1 and A2A receptors (Ki values are 2200 and 24000 nM respectively). Produces potent analgesic effects in vivo .

top caption :

Selective human A2B antagonist; water-soluble

extended description :

Selective human A2B antagonist; water-soluble

chemical name text :

4-(2,3,6,7-Tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)-benzenesulfonic acid

formula :

C14H14N4O5S

formula text :

C14H14N4O5S

cas num :

152529-79-8

USD :

218 USD

product details :

Selective human A2B antagonist; water-soluble

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage