Fluticasone propionate | Tocris Bioscience 2007/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Fluticasone propionate

catalog :

2007/10

quantity :

10 mg (also 50 mg)

price :

238 USD

more info or order :

Tocris Bioscience product webpage

citations: 1

Reference
Burke S, Goff M, Updegraff B, Lu D, Brown P, Minkin S, et al. Regulation of the CCL2 gene in pancreatic ?-cells by IL-1? and glucocorticoids: role of MKP-1. PLoS ONE. 2012;7:e46986 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2007

SKU :

2007/10

product name :

Fluticasone propionate

description :

Selective high affinity glucocorticoid receptor agonist

target :

Glucocorticoid Receptor Agonists

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at RT

observed molecular weight :

500.57

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Fluticasone propionate is a high affinity, selective glucocorticoid receptor agonist (Kd = 0.5 nM). Potently stimulates glucocorticoid receptor-mediated transactivation of gene expression and enhances human eosinophil apoptosis (EC50 = 3.7 nM) in vitro . Inhibits mast cell accumulation in nasal mucosa following topical administration. Lipophilic anti-inflammatory agent with low oral bioavailability. Also potentiates KV1 channels (EC50 = 37 nM).

product keywords :

Selective high affinity glucocorticoid agonists Receptors GlaxoSmithKline GSK Glucocorticoid Receptor Voltage-Gated Potassium Channels 2007,

extended description :

Selective high affinity glucocorticoid receptor agonist

chemical name text :

(6 ,11 ,16 ,17 )-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester

formula :

C25H31F3O5S

formula text :

C25H31F3O5S

cas num :

80474-14-2

USD :

235

USD 2025 :

238 USD

product details :

Selective high affinity glucocorticoid receptor agonist

more info or order :

Tocris Bioscience product webpage