Paxilline | Tocris Bioscience 2006 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Paxilline

catalog :

2006

quantity :

10 mg

price :

296 USD

more info or order :

Tocris Bioscience product webpage

citations: 19

Reference
Fernández Fernández D, Cadaveira Mosquera A, Rueda Ruzafa L, Herrera Pérez S, Veale E, Reboreda A, et al. Activation of TREK currents by riluzole in three subgroups of cultured mouse nodose ganglion neurons. PLoS ONE. 2018;13:e0199282 pubmed publisher
Madry C, Kyrargyri V, Arancibia Carcamo I, Jolivet R, Kohsaka S, Bryan R, et al. Microglial Ramification, Surveillance, and Interleukin-1? Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1. Neuron. 2018;97:299-312.e6 pubmed publisher
Abrahao K, Chancey J, Chan C, Lovinger D. Ethanol-Sensitive Pacemaker Neurons in the Mouse External Globus Pallidus. Neuropsychopharmacology. 2017;42:1070-1081 pubmed publisher
Whitt J, Montgomery J, Meredith A. BK channel inactivation gates daytime excitability in the circadian clock. Nat Commun. 2016;7:10837 pubmed publisher
Simkin D, Hattori S, YBARRA N, Musial T, Buss E, Richter H, et al. Aging-Related Hyperexcitability in CA3 Pyramidal Neurons Is Mediated by Enhanced A-Type K+ Channel Function and Expression. J Neurosci. 2015;35:13206-18 pubmed publisher
Kim K, Iddings J, Stern J, Blanco V, Croom D, Kirov S, et al. Astrocyte contributions to flow/pressure-evoked parenchymal arteriole vasoconstriction. J Neurosci. 2015;35:8245-57 pubmed publisher
Hirono M, Ogawa Y, Misono K, Zollinger D, Trimmer J, Rasband M, et al. BK Channels Localize to the Paranodal Junction and Regulate Action Potentials in Myelinated Axons of Cerebellar Purkinje Cells. J Neurosci. 2015;35:7082-94 pubmed publisher
Lai M, Wu Y, Gao Z, Anderson M, Dalziel J, Meredith A. BK channels regulate sinoatrial node firing rate and cardiac pacing in vivo. Am J Physiol Heart Circ Physiol. 2014;307:H1327-38 pubmed publisher
Parajuli S, Provence A, Petkov G. Prostaglandin E2 excitatory effects on guinea pig urinary bladder smooth muscle: a novel regulatory mechanism mediated by large-conductance voltage- and Ca2+-activated K+ channels. Eur J Pharmacol. 2014;738:179-85 pubmed publisher
Ksiazek A, Ladno W, Szulczyk B, Grzelka K, Szulczyk P. Properties of BK-type Ca(+) (+)-dependent K(+) channel currents in medial prefrontal cortex pyramidal neurons in rats of different ages. Front Cell Neurosci. 2013;7:185 pubmed publisher
Wan E, Kushner J, Zakharov S, Nui X, Chudasama N, Kelly C, et al. Reduced vascular smooth muscle BK channel current underlies heart failure-induced vasoconstriction in mice. FASEB J. 2013;27:1859-67 pubmed publisher
Montgomery J, Whitt J, Wright B, Lai M, Meredith A. Mis-expression of the BK K(+) channel disrupts suprachiasmatic nucleus circuit rhythmicity and alters clock-controlled behavior. Am J Physiol Cell Physiol. 2013;304:C299-311 pubmed publisher
Pulkkinen V, Manson M, Säfholm J, Adner M, Dahlen S. The bitter taste receptor (TAS2R) agonists denatonium and chloroquine display distinct patterns of relaxation of the guinea pig trachea. Am J Physiol Lung Cell Mol Physiol. 2012;303:L956-66 pubmed publisher
Westcott E, Goodwin E, Segal S, Jackson W. Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles. J Physiol. 2012;590:1849-69 pubmed publisher
Bodhinathan K, Kumar A, Foster T. Redox sensitive calcium stores underlie enhanced after hyperpolarization of aged neurons: role for ryanodine receptor mediated calcium signaling. J Neurophysiol. 2010;104:2586-93 pubmed publisher
Gittis A, Moghadam S, du Lac S. Mechanisms of sustained high firing rates in two classes of vestibular nucleus neurons: differential contributions of resurgent Na, Kv3, and BK currents. J Neurophysiol. 2010;104:1625-34 pubmed publisher
Zhang H, Xie M, Schools G, Feustel P, Wang W, Lei T, et al. Tamoxifen mediated estrogen receptor activation protects against early impairment of hippocampal neuron excitability in an oxygen/glucose deprivation brain slice ischemia model. Brain Res. 2009;1247:196-211 pubmed publisher
Zhang H, Schools G, Lei T, Wang W, Kimelberg H, Zhou M. Resveratrol attenuates early pyramidal neuron excitability impairment and death in acute rat hippocampal slices caused by oxygen-glucose deprivation. Exp Neurol. 2008;212:44-52 pubmed publisher
Pyott S, Glowatzki E, Trimmer J, Aldrich R. Extrasynaptic localization of inactivating calcium-activated potassium channels in mouse inner hair cells. J Neurosci. 2004;24:9469-74 pubmed

product information

brand :

Tocris

master code :

2006

SKU :

2006/10

product name :

Paxilline

description :

SERCA ATPase blocker. Also potent BKCa channel blocker

target :

Ca2+-ATPase Blockers

category :

Small Molecules

unit size :

10 mg

purity :

98%

observed molecular weight :

435.56

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels. Binds to the -subunit of BKCa (Ki = 1.9 nM for block of currents in -subunit-expressing oocytes) and enhances binding of charybdotoxin to BKCa channels in vascular smooth muscle. Also inhibits sarco/endoplasmic reticulum Ca2+-ATPase (IC50 = 5 - 50 u M).

catalog number base :

2006

product keywords :

Potent blockers BKCa channels SERCA ATPases Potassium ca2+-activated ca2+-dependent Ca2+-ATPase Signaling Signalling Calcium Calcium-ATPase Ion Transporters Pumps Ca2+-Activated Potassium Channels Ca2+-ATPase 2006,

extended description :

SERCA ATPase blocker. Also potent BKCa channel blocker

chemical name text :

(2R,4bS,6aS,12bS,12cR,14aS)-5,6,6a,7,12,12b,12c,13,14,14a-Decahydro-4b-hydroxy-2-(1-hydroxy-1-methylethyl)-12b,12c-dimethyl-2H-pyrano[2 ,3 :5 ,6 ]benz[1 ,2 :6,7]indeno[1,2-b]indol-3(4bH)-one

formula :

C 27 H 33 NO 4

formula text :

C27H33NO4

cas num :

57186-25-1

2020 USD :

281

2021 USD :

296 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage