Isradipine | Tocris Bioscience 2004 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Isradipine

catalog :

2004

quantity :

10 mg (also 50 mg)

price :

151 USD

more info or order :

Tocris Bioscience product webpage

citations: 6

Reference
McKeithan W, Savchenko A, YU M, Cerignoli F, Bruyneel A, Price J, et al. An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes. Front Physiol. 2017;8:766 pubmed publisher
Winland C, Welsh N, Sepulveda Rodriguez A, Vicini S, Maguire Zeiss K. Inflammation alters AMPA-stimulated calcium responses in dorsal striatal D2 but not D1 spiny projection neurons. Eur J Neurosci. 2017;46:2519-2533 pubmed publisher
Pourbadie H, Naderi N, Mehranfard N, Janahmadi M, Khodagholi F, Motamedi F. Preventing effect of L-type calcium channel blockade on electrophysiological alterations in dentate gyrus granule cells induced by entorhinal amyloid pathology. PLoS ONE. 2015;10:e0117555 pubmed publisher
Dragicevic E, Poetschke C, Duda J, Schlaudraff F, Lammel S, Schiemann J, et al. Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain. 2014;137:2287-302 pubmed publisher
Saszik S, DeVries S. A mammalian retinal bipolar cell uses both graded changes in membrane voltage and all-or-nothing Na+ spikes to encode light. J Neurosci. 2012;32:297-307 pubmed publisher
Murray K, Stephens M, Rank M, D Amico J, Gorassini M, Bennett D. Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors. J Neurophysiol. 2011;106:925-43 pubmed publisher

product information

brand :

Tocris

master code :

2004

SKU :

2004/10

product name :

Isradipine

description :

CaV1.x blocker

target :

Voltage-gated Calcium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

371.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent and selective L-type voltage-gated Ca2+ channel blocker. EC50 and pA2 values are 1.4 nM and 10.3 for relaxation of depolarization- and Ca2+-induced contractions of rabbit aorta respectively; EC25 = 0.45 nM for reduction in rate of spontaneously beating guinea pig right atria. Long-acting antihypertensive agent in vivo , exerting primary effects on vascular tissue with secondary negative chronotropic action.

catalog number base :

2004

product keywords :

Ca2+ channel blockers L-type Calcium CaV Channels voltage-gated voltage-dependent PN200110 PN 200-110 Cav1.x Channels 2004, Voltage-gated calcium channel blocker, voltage gated calcium channel, high-voltage activated Ca2+ channel, high voltage gated ca2+ channel

extended description :

CaV1.x blocker

chemical name text :

4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester

formula :

C 19 H 21 N 3 O 5

formula text :

C19H21N3O5

cas num :

75695-93-1

2020 USD :

145

2021 USD :

151 USD

alt names :

PN 200-110

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage