Ro 31-8220 mesylate | Tocris Bioscience 2002/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ro 31-8220 mesylate

catalog :

2002/10

quantity :

10 mg

price :

338 USD

more info or order :

Tocris Bioscience product webpage

citations: 7

Reference
Duan T, Cil O, Thiagarajah J, Verkman A. Intestinal epithelial potassium channels and CFTR chloride channels activated in ErbB tyrosine kinase inhibitor diarrhea. JCI Insight. 2019;4: pubmed publisher
Schneberger D, Devasure J, Kirychuk S, Wyatt T. Organic barn dust inhibits surfactant protein D production through protein kinase-c alpha dependent increase of GPR116. PLoS ONE. 2018;13:e0208597 pubmed publisher
Mou H, Vinarsky V, Tata P, Brazauskas K, Choi S, Crooke A, et al. Dual SMAD Signaling Inhibition Enables Long-Term Expansion of Diverse Epithelial Basal Cells. Cell Stem Cell. 2016;19:217-231 pubmed publisher
Tang B, Luo D, Yang J, Xu X, Zhu B, Wang X, et al. Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex. Sci Rep. 2015;5:14099 pubmed publisher
Ortinski P, Briand L, Pierce R, Schmidt H. Cocaine-seeking is associated with PKC-dependent reduction of excitatory signaling in accumbens shell D2 dopamine receptor-expressing neurons. Neuropharmacology. 2015;92:80-9 pubmed publisher
Bailey T, Luan H, Tom E, Bielecki T, Mohapatra B, Ahmad G, et al. A kinase inhibitor screen reveals protein kinase C-dependent endocytic recycling of ErbB2 in breast cancer cells. J Biol Chem. 2014;289:30443-58 pubmed publisher
Bayliss A, Evans P. Characterisation of AmphiAmR11, an amphioxus (Branchiostoma floridae) D2-dopamine-like G protein-coupled receptor. PLoS ONE. 2013;8:e80833 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

2002

SKU :

2002/10

product name :

Ro 31-8220 mesylate

description :

Protein kinase inhibitor

target :

Broad Spectrum Protein Kinase Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

97%

storage :

Desiccate at -20°C

observed molecular weight :

553.65

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ro 31-8220 mesylate is a protein kinase C inhibitor, with activity at other protein kinases (IC50 values are 33, 3, 8, 15 and 38 nM for PKC , MAPKAP-K1b, MSK1, GSK3 and S6K1 respectively). Activates JNK and glycogen synthase, and inhibits MAPK and ERK2, in rat adipocytes and L6 myotubes. Also inhibits voltage-dependent Na+ channels in the micromolar range. Induces protein-protein interaction between mutant SMAD4R361H and SMAD3, leading to reactivation of dormant SMAD4R361H-mediated transcriptional activity and restoration of TGF- -induced tumor suppression activity in SMAD4 mutant cancer cells.

product keywords :

Protein kinases inhibitors inhibits Broad Spectrum Ro31-8220 mesylate protein-protein interaction inducers induces SMAD4 SMAD3 TGF-beta TGF-B TGF- Bisindolylmaleimide IX Broad Spectrum Protein Kinase Inhibitors TGF-beta Receptors 2002,

extended description :

Protein kinase inhibitor

chemical name text :

3-[3-[2,5-Dihydro-4-(1-methyl-1H-indol-3-yl)-2,5-dioxo-1H-pyrrol-3-yl]-1H-indol-1-yl]propyl carbamimidothioic acid ester mesylate

formula :

C25H23N5O2S.CH3SO3H

formula text :

C25H23N5O2S.CH3SO3H

cas num :

138489-18-6

USD :

334

USD 2025 :

338 USD

product details :

Protein kinase inhibitor

alt names :

Bisindolylmaleimide IX

more info or order :

Tocris Bioscience product webpage