GS 39783 | Tocris Bioscience 2001 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

GS 39783

catalog :

2001

quantity :

10 mg (also 50 mg)

price :

168 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Zhang W, Xu C, Tu H, Wang Y, Sun Q, Hu P, et al. GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Sci Rep. 2015;5:10468 pubmed publisher
Pacey L, Tharmalingam S, Hampson D. Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. J Pharmacol Exp Ther. 2011;338:897-905 pubmed publisher

product information

brand :

Tocris

master code :

2001

SKU :

2001/10

product name :

GS 39783

description :

Positive allosteric modulator of GABAB receptors

target :

GABA-B Receptor Modulators

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

337.44

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Positive allosteric modulator of GABAB receptor function. Potentiates the effects of GABA on [35S]GTP S binding at recombinant and native GABAB receptors (EC50 values are 2.1 and 3.1 u M respectively). Decreases cocaine self-administration, blocks the rewarding properties of nicotine and produces anxiolytic-like activity without the side effects associated with baclofen or benzodiazepines.

catalog number base :

2001

product keywords :

Positive modulators GABAB receptors GS39783 PAM GABAB Receptors 2001,

extended description :

Positive allosteric modulator of GABAB receptors

chemical name text :

N,N -Dicyclopentyl-2-(methylthio)-5-nitro-4,6-pyrimidinediamine

formula :

C 15 H 23 N 5 O 2 S

formula text :

C15H23N5O2S

cas num :

39069-52-8

2020 USD :

163

2021 USD :

168 USD

storage :

Store at RT

more info or order :

Tocris Bioscience product webpage