Linopirdine dihydrochloride | Tocris Bioscience 1999 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Linopirdine dihydrochloride

catalog :

1999

quantity :

10 mg (also 50 mg)

price :

195 USD

more info or order :

Tocris Bioscience product webpage

citations: 12

Reference
Greene D, Kang S, Hoshi N. XE991 and Linopirdine Are State-Dependent Inhibitors for Kv7/KCNQ Channels that Favor Activated Single Subunits. J Pharmacol Exp Ther. 2017;362:177-185 pubmed publisher
Lecrux C, Sandoe C, Neupane S, Kropf P, Toussay X, Tong X, et al. Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation. J Neurosci. 2017;37:1518-1531 pubmed publisher
Ghezzi F, Corsini S, Nistri A. Electrophysiological characterization of the M-current in rat hypoglossal motoneurons. Neuroscience. 2017;340:62-75 pubmed publisher
Carrott L, Bowl M, Aguilar C, Johnson S, Chessum L, West M, et al. Absence of Neuroplastin-65 Affects Synaptogenesis in Mouse Inner Hair Cells and Causes Profound Hearing Loss. J Neurosci. 2016;36:222-34 pubmed publisher
Zampini V, Johnson S, Franz C, Knipper M, Holley M, Magistretti J, et al. Fine Tuning of CaV1.3 Ca2+ channel properties in adult inner hair cells positioned in the most sensitive region of the Gerbil Cochlea. PLoS ONE. 2014;9:e113750 pubmed publisher
Sedivy V, Joshi S, Ghaly Y, Mizera R, Žaloudíková M, Brennan S, et al. Role of Kv7 channels in responses of the pulmonary circulation to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2015;308:L48-57 pubmed publisher
Lee B, Ryu P, Lee S. Serum starvation-induced voltage-gated potassium channel Kv7.5 expression and its regulation by Sp1 in canine osteosarcoma cells. Int J Mol Sci. 2014;15:977-93 pubmed publisher
Zampini V, Johnson S, Franz C, Knipper M, Holley M, Magistretti J, et al. Burst activity and ultrafast activation kinetics of CaV1.3 Ca²? channels support presynaptic activity in adult gerbil hair cell ribbon synapses. J Physiol. 2013;591:3811-20 pubmed publisher
Gigout S, Jones G, Wierschke S, Davies C, Watson J, Deisz R. Distinct muscarinic acetylcholine receptor subtypes mediate pre- and postsynaptic effects in rat neocortex. BMC Neurosci. 2012;13:42 pubmed publisher
Anderson U, Carson C, McCloskey K. KCNQ currents and their contribution to resting membrane potential and the excitability of interstitial cells of Cajal from the guinea pig bladder. J Urol. 2009;182:330-6 pubmed publisher
Luther J, Birren S. p75 and TrkA signaling regulates sympathetic neuronal firing patterns via differential modulation of voltage-gated currents. J Neurosci. 2009;29:5411-24 pubmed publisher
Joshi S, Sedivy V, Hodyc D, Herget J, Gurney A. KCNQ modulators reveal a key role for KCNQ potassium channels in regulating the tone of rat pulmonary artery smooth muscle. J Pharmacol Exp Ther. 2009;329:368-76 pubmed publisher

product information

brand :

Tocris

master code :

1999

SKU :

1999/10

product name :

Linopirdine dihydrochloride

description :

KV7 (KCNQ) channel blocker

target :

Voltage-gated Potassium Channel Blockers

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

464.39

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Blocker of KV7 (KCNQ) voltage-gated potassium channels; blocks KV7.1 + 7.3 (KCNQ2 + 3)/ M-currents (IC50 = 4 - 7 u M) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 u M). Augments hippocampal ACh release and is a cognitive enhancer following oral administration in vivo .

catalog number base :

1999

product keywords :

KCNQ channel blockers Potassium KV kv7 Channels voltage-gated voltage-dependent K+ KCNQ2 KCNQ3 KCNQ1 DuP996 DuP 996 Voltage-Gated Potassium Channels 1999,

extended description :

KV7 (KCNQ) channel blocker

chemical name text :

1,3-Dihydro-1-phenyl-3,3-bis(4-pyridinylmethyl)-2H-indol-2-one dihydrochloride

formula :

C 26 H 21 N 3 O.2HCl

formula text :

C26H21N3O.2HCl

cas num :

113168-57-3

2020 USD :

187

2021 USD :

195 USD

alt names :

DuP 996

storage :

Desiccate at RT

more info or order :

Tocris Bioscience product webpage