Ro 15-4513 | Tocris Bioscience 1997/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Ro 15-4513

catalog :

1997/10

quantity :

10 mg (also 50 mg)

price :

174 USD

more info or order :

Tocris Bioscience product webpage

citations: 2

Reference
Tracy M, Banks M, Shelton K. Negative allosteric modulation of GABAA receptors inhibits facilitation of brain stimulation reward by drugs of abuse in C57BL6/J mice. Psychopharmacology (Berl). 2016;233:715-25 pubmed publisher
Koh M, Rosenzweig Lipson S, Gallagher M. Selective GABA(A) ?5 positive allosteric modulators improve cognitive function in aged rats with memory impairment. Neuropharmacology. 2013;64:145-52 pubmed publisher

product information

brand :

Tocris

master code :

1997

SKU :

1997/10

product name :

Ro 15-4513

description :

Benzodiazepine partial inverse agonist

target :

Benzodiazepine Inverse Agonists

category :

Small Molecules

unit sizes :

10 mg (also 50 mg)

purity :

98%

observed molecular weight :

326.31

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Ro 15-4513 is a high affinity benzodiazepine ligand. Ki values are 3.1 and 5.3 nM for diazepam-insensitive (DI) and diazepam-sensitive (DS) benzodiazepine receptors respectively. Acts as partial inverse agonist at recombinant DS 1-, 2-, 3- and 5-GABAA receptors. Displays partial agonism at DI 4- and 6-GABAA receptors. Antagonizes several behavioral and neurochemical effects of ethanol. Proconvulsant and anxiogenic.

extended description :

Benzodiazepine partial inverse agonist

chemical name text :

8-Azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester

formula :

C 15 H 14 N 6 O 3

formula text :

C15H14N6O3

cas num :

91917-65-6

USD :

174 USD

product details :

Benzodiazepine partial inverse agonist

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage