product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
MPP dihydrochloride
catalog :
1991/10
quantity :
10 mg (also 50 mg)
price :
239 USD
more info or order :
citations: 29
Reference
Karaboğa Arslan A, Yerer M. ?-Chaconine and ?-Solanine Inhibit RL95-2 Endometrium Cancer Cell Proliferation by Reducing Expression of Akt (Ser473) and ER? (Ser167). Nutrients. 2018;10: pubmed publisher
Al Khyatt W, Tufarelli C, Khan R, Iftikhar S. Selective oestrogen receptor antagonists inhibit oesophageal cancer cell proliferation in vitro. BMC Cancer. 2018;18:121 pubmed publisher
Fátima L, Campello R, Santos R, Freitas H, Frank A, Machado U, et al. Estrogen receptor 1 (ESR1) regulates VEGFA in adipose tissue. Sci Rep. 2017;7:16716 pubmed publisher
Luo F, Huang W, Guo Y, Ruan G, Peng R, Li X. 17?-estradiol lowers triglycerides in adipocytes via estrogen receptor ? and it may be attenuated by inflammation. Lipids Health Dis. 2017;16:182 pubmed publisher
Villar Pazos S, Martinez Pinna J, Castellano Muñoz M, Alonso Magdalena P, Marroquí L, Quesada I, et al. Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on ca2+ entry in mouse pancreatic β-cells. Sci Rep. 2017;7:11770 pubmed publisher
Lou Y, Hu M, Wang Q, Yuan M, Wang N, Le F, et al. Estradiol Suppresses TLR4-triggered Apoptosis of Decidual Stromal Cells and Drives an Anti-inflammatory TH2 Shift by Activating SGK1. Int J Biol Sci. 2017;13:434-448 pubmed publisher
Caballero I, Boyd J, Almiñana C, Sánchez López J, Basatvat S, Montazeri M, et al. Understanding the dynamics of Toll-like Receptor 5 response to flagellin and its regulation by estradiol. Sci Rep. 2017;7:40981 pubmed publisher
Wójtowicz A, Szychowski K, Wnuk A, Kajta M. Dibutyl Phthalate (DBP)-Induced Apoptosis and Neurotoxicity are Mediated via the Aryl Hydrocarbon Receptor (AhR) but not by Estrogen Receptor Alpha (ERα), Estrogen Receptor Beta (ERβ), or Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) in Mo. Neurotox Res. 2017;31:77-89 pubmed publisher
Pastore M, Talwar S, Conley M, Magness R. Identification of Differential ER-Alpha Versus ER-Beta Mediated Activation of eNOS in Ovine Uterine Artery Endothelial Cells. Biol Reprod. 2016;94:139 pubmed publisher
Xing L, Esau C, Trudeau V. Direct Regulation of Aromatase B Expression by 17β-Estradiol and Dopamine D1 Receptor Agonist in Adult Radial Glial Cells. Front Neurosci. 2015;9:504 pubmed publisher
Bertrand S, Hu C, Aksenova M, Mactutus C, Booze R. HIV-1 Tat and cocaine mediated synaptopathy in cortical and midbrain neurons is prevented by the isoflavone Equol. Front Microbiol. 2015;6:894 pubmed publisher
Wang L, Qiu X, Gui Y, Xu Y, Gober H, Li D. Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α. Drug Des Devel Ther. 2015;9:3755-66 pubmed publisher
Gao X, Ma J, Chen Y, Wang H. Rapid responses and mechanism of action for low-dose bisphenol S on ex vivo rat hearts and isolated myocytes: evidence of female-specific proarrhythmic effects. Environ Health Perspect. 2015;123:571-8 pubmed publisher
Mazzuca M, Mata K, Li W, Rangan S, Khalil R. Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat. J Pharmacol Exp Ther. 2015;352:291-304 pubmed publisher
Koong L, Watson C. Direct estradiol and diethylstilbestrol actions on early- versus late-stage prostate cancer cells. Prostate. 2014;74:1589-603 pubmed publisher
Gorelick D, Iwanowicz L, Hung A, Blazer V, Halpern M. Transgenic zebrafish reveal tissue-specific differences in estrogen signaling in response to environmental water samples. Environ Health Perspect. 2014;122:356-62 pubmed publisher
Kim M, Cho S, Lee K, Han H, Song T, Park S. Effects of 17?-estradiol and estrogen receptor antagonists on the proliferation of gastric cancer cell lines. J Gastric Cancer. 2013;13:172-8 pubmed publisher
Gao X, Liang Q, Chen Y, Wang H. Molecular mechanisms underlying the rapid arrhythmogenic action of bisphenol A in female rat hearts. Endocrinology. 2013;154:4607-17 pubmed publisher
Cruz D, Koishi A, Taniguchi J, Li X, Milan Bonotto R, No J, et al. High content screening of a kinase-focused library reveals compounds broadly-active against dengue viruses. PLoS Negl Trop Dis. 2013;7:e2073 pubmed publisher
Giordano G, Tait L, Furlong C, Cole T, Kavanagh T, Costa L. Gender differences in brain susceptibility to oxidative stress are mediated by levels of paraoxonase-2 expression. Free Radic Biol Med. 2013;58:98-108 pubmed publisher
Privette Vinnedge L, Ho S, Wikenheiser Brokamp K, Wells S. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PLoS ONE. 2012;7:e46985 pubmed publisher
Lam H, Suresh Babu C, Wang J, Yuan Y, Lam Y, Ho S, et al. Phosphorylation of human estrogen receptor-beta at serine 105 inhibits breast cancer cell migration and invasion. Mol Cell Endocrinol. 2012;358:27-35 pubmed publisher
Liu N, Chakrabarti S, Schnell S, Wessendorf M, Gintzler A. Spinal synthesis of estrogen and concomitant signaling by membrane estrogen receptors regulate spinal ?- and ?-opioid receptor heterodimerization and female-specific spinal morphine antinociception. J Neurosci. 2011;31:11836-45 pubmed publisher
Zhang H, Feng L, Wang W, Magness R, Chen D. Estrogen-responsive nitroso-proteome in uterine artery endothelial cells: role of endothelial nitric oxide synthase and estrogen receptor-?. J Cell Physiol. 2012;227:146-59 pubmed publisher
Dhillon S, Belsham D. Estrogen inhibits NPY secretion through membrane-associated estrogen receptor (ER)-? in clonal, immortalized hypothalamic neurons. Int J Obes (Lond). 2011;35:198-207 pubmed publisher
Chan Q, Lam H, Ng C, Lee A, Chan E, Ng H, et al. Activation of GPR30 inhibits the growth of prostate cancer cells through sustained activation of Erk1/2, c-jun/c-fos-dependent upregulation of p21, and induction of G(2) cell-cycle arrest. Cell Death Differ. 2010;17:1511-23 pubmed publisher
Sobrino A, Oviedo P, Novella S, Laguna Fernandez A, Bueno C, García Pérez M, et al. Estradiol selectively stimulates endothelial prostacyclin production through estrogen receptor-{alpha}. J Mol Endocrinol. 2010;44:237-46 pubmed publisher
Le May C, Chu K, Hu M, Ortega C, Simpson E, Korach K, et al. Estrogens protect pancreatic beta-cells from apoptosis and prevent insulin-deficient diabetes mellitus in mice. Proc Natl Acad Sci U S A. 2006;103:9232-7 pubmed
Dong J, Tsai Morris C, Dufau M. A novel estradiol/estrogen receptor alpha-dependent transcriptional mechanism controls expression of the human prolactin receptor. J Biol Chem. 2006;281:18825-36 pubmed
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
1991
SKU :
1991/10
product name :
MPP dihydrochloride
description :
Highly selective ER antagonist
target :
Estrogen and Related Receptor Antagonists
unit size :
10 mg (also 50 mg)
category :
Small Molecules
purity :
98%
storage :
Store at +4°C
observed molecular weight :
542.5
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
MPP dihydrochloride is a selective, high affinity silent antagonist at ER receptors. Displays 200-fold selectivity for ER over ER . Ki values are 2.7 and 1800 nM at ER and ER receptors respectively.
product keywords :
selective Erα receptor antagonist; ERalpha antagonists ER ERR Estrogen Receptors Estrogen and Related Receptors 1991,
extended description :
Highly selective ER antagonist
chemical name text :
1,3-Bis(4-hydroxyphenyl)-4-methyl-5-[4-(2-piperidinylethoxy)phenol]-1H-pyrazole dihydrochloride
formula :
C29H31N3O3.2HCl
formula text :
C29H31N3O3.2HCl
cas num :
911295-24-4
USD :
232
USD 2025 :
239 USD
product details :
Highly selective ER antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK