product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
(R,R)-THC
catalog :
1990/10
quantity :
10 mg
price :
439 USD
more info or order :
citations: 8
Reference
Vona R, Gambardella L, Ortona E, Santulli M, Malorni W, Carè A, et al. Functional Estrogen Receptors of Red Blood Cells. Do They Influence Intracellular Signaling?. Cell Physiol Biochem. 2019;53:186-199 pubmed publisher
Wang L, Qiu X, Gui Y, Xu Y, Gober H, Li D. Bu-Shen-Ning-Xin decoction: inhibition of osteoclastogenesis by abrogation of the RANKL-induced NFATc1 and NF-κB signaling pathways via selective estrogen receptor α. Drug Des Devel Ther. 2015;9:3755-66 pubmed publisher
Nicholson T, Moses M, Uchtmann K, Keil K, Bjorling D, Vezina C, et al. Estrogen receptor-α is a key mediator and therapeutic target for bladder complications of benign prostatic hyperplasia. J Urol. 2015;193:722-9 pubmed publisher
Li H, Wood J, Whitten K, Vadivel S, Seng S, Makriyannis A, et al. Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells. Br J Pharmacol. 2013;170:489-505 pubmed publisher
Simpkins F, Hevia Paez P, Sun J, Ullmer W, Gilbert C, Da Silva T, et al. Src Inhibition with saracatinib reverses fulvestrant resistance in ER-positive ovarian cancer models in vitro and in vivo. Clin Cancer Res. 2012;18:5911-23 pubmed publisher
Xing D, Oparil S, Yu H, Gong K, Feng W, Black J, et al. Estrogen modulates NF?B signaling by enhancing I?B? levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-?. PLoS ONE. 2012;7:e36890 pubmed publisher
Guo A, Choi R, Cheung A, Chen V, Xu S, Dong T, et al. Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/beta-catenin signaling pathway. J Biol Chem. 2011;286:27882-93 pubmed publisher
Kola B, Farkas I, Christ Crain M, Wittmann G, Lolli F, Amin F, et al. The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system. PLoS ONE. 2008;3:e1797 pubmed publisher
product information
brand :
Tocris
catalog number base :
1990
SKU :
1990/10
product name :
(R,R)-THC
units size :
10 mg
description :
Potent subtype-selective ligand; ER agonist/ER antagonist
target :
Additional Estrogen and Related Receptor Compounds
category :
Small Molecules
purity :
98%
observed molecular weight :
320.42
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
( R , R )-THC is a non-steroidal, selective estrogen receptor ligand. ( R , R )-THC is an agonist at ER receptor (Ki = 9.0 nM) and antagonist at ER receptor (Ki = 3.6 nM).
top caption :
Potent subtype-selective ligand; ER agonist/ER antagonist
extended description :
Potent subtype-selective ligand; ER agonist/ER antagonist
chemical name text :
(R,R)-5,11-Diethyl-5,6,11,12-tetrahydro-2,8-chrysenediol
formula :
C22H24O2
formula text :
C22H24O2
cas num :
138090-06-9
USD :
439 USD
product details :
Potent subtype-selective ligand; ER agonist/ER antagonist
storage :
Store at -20°C
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK