Leptomycin B | Tocris Bioscience 1987 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Leptomycin B

catalog :

1987

quantity :

5 ug

price :

367 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Zheng W, Fan W, Zhang S, Jiao P, Shang Y, Cui L, et al. Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export. Cell Rep. 2019;27:1875-1885.e5 pubmed publisher
Cao S, Jiang J, Li J, Li Y, Yang L, Wang S, et al. Characterization of the nucleocytoplasmic shuttle of the matrix protein of influenza B virus. J Virol. 2014;88:7464-73 pubmed publisher
Horan K, Hansen K, Jakobsen M, Holm C, Søby S, Unterholzner L, et al. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors. J Immunol. 2013;190:2311-9 pubmed publisher
Cao S, Liu X, Yu M, Li J, Jia X, Bi Y, et al. A nuclear export signal in the matrix protein of Influenza A virus is required for efficient virus replication. J Virol. 2012;86:4883-91 pubmed publisher

product information

brand :

Tocris

master code :

1987

SKU :

1987/5U

product name :

Leptomycin B

description :

Inhibits nuclear export of proteins; antitumor

target :

Translocation, Exo/Endocytosis Products

category :

Small Molecules

unit size :

5 ug

observed molecular weight :

540.74

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo .

catalog number base :

1987

product keywords :

inhibitors inhibits nuclear export proteins antitumor Protein Translocation LeptomycinB CI940 antibiotics CI 940 LMB Translocation, Exocytosis & Endocytosis Antibiotics Antifungals Translocation 1987,

extended description :

Inhibits nuclear export of proteins; antitumor

chemical name text :

(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

formula :

C 33 H 48 O 6

formula text :

C33H48O6

cas num :

87081-35-4

2020 USD :

356

2021 USD :

367 USD

alt names :

CI 940, LMB

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage