Leptomycin B | Tocris Bioscience 1987/5U product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Leptomycin B

catalog :

1987/5U

quantity :

5 ug

price :

367 USD

citations: 4

Reference
Zheng W, Fan W, Zhang S, Jiao P, Shang Y, Cui L, et al. Naproxen Exhibits Broad Anti-influenza Virus Activity in Mice by Impeding Viral Nucleoprotein Nuclear Export. Cell Rep. 2019;27:1875-1885.e5 pubmed publisher
Cao S, Jiang J, Li J, Li Y, Yang L, Wang S, et al. Characterization of the nucleocytoplasmic shuttle of the matrix protein of influenza B virus. J Virol. 2014;88:7464-73 pubmed publisher
Horan K, Hansen K, Jakobsen M, Holm C, Søby S, Unterholzner L, et al. Proteasomal degradation of herpes simplex virus capsids in macrophages releases DNA to the cytosol for recognition by DNA sensors. J Immunol. 2013;190:2311-9 pubmed publisher
Cao S, Liu X, Yu M, Li J, Jia X, Bi Y, et al. A nuclear export signal in the matrix protein of Influenza A virus is required for efficient virus replication. J Virol. 2012;86:4883-91 pubmed publisher

product information

brand :

Tocris

SKU :

1987/5U

product name :

Leptomycin B

unit sizes :

5 ug

description :

Inhibits nuclear export of proteins; antitumor

target :

Translocation, Exo /Endocytosis Products

category :

Small Molecules

storage :

Desiccate at -20°C

observed molecular weight :

540.74

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Antifungal antibiotic that is an inhibitor of the nuclear export of proteins; acts by binding directly to and inhibiting CRM1/exportin-1. Inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Antitumor in vitro and in vivo .

catalog number base :

1987

extended description :

Inhibits nuclear export of proteins; antitumor

chemical name text :

(2E,5S,6R,7S,9R,10E,12E,15R,16Z,18E)-19-[(2S,3S)-3,6-Dihydro-3-methyl-6-oxo-2H-pyran-2-yl]-17-ethyl-6-hydroxy-3,5,7,9,11,15-hexamethyl-8-oxo-2,10,12,16,18-nonadecapentaenoic acid

formula :

C 33 H 48 O 6

formula text :

C33H48O6

cas num :

87081-35-4

USD :

367 USD

default size :

TRUE

product details :

Inhibits nuclear export of proteins; antitumor

alt names :

CI 940, LMB