Reboxetine mesylate | Tocris Bioscience 1982/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Reboxetine mesylate

catalog :

1982/10

quantity :

10 mg (also 50 mg)

price :

272 USD

more info or order :

Tocris Bioscience product webpage

citations: 9

Reference
Kreiner G, Rafa Zabłocka K, Barut J, Chmielarz P, Kot M, Bagińska M, et al. Stimulation of noradrenergic transmission by reboxetine is beneficial for a mouse model of progressive parkinsonism. Sci Rep. 2019;9:5262 pubmed publisher
Zhu Y, Ma Y, Elefteriou F. Cortical bone is an extraneuronal site of norepinephrine uptake in adult mice. Bone Rep. 2018;9:188-198 pubmed publisher
Munari L, Provensi G, Passani M, Galeotti N, Cassano T, Benetti F, et al. Brain Histamine Is Crucial for Selective Serotonin Reuptake Inhibitors' Behavioral and Neurochemical Effects. Int J Neuropsychopharmacol. 2015;18:pyv045 pubmed publisher
Suto T, Eisenach J, Hayashida K. Peripheral nerve injury and gabapentin, but not their combination, impair attentional behavior via direct effects on noradrenergic signaling in the brain. Pain. 2014;155:1935-42 pubmed publisher
Hughes S, Hickey L, Hulse R, Lumb B, Pickering A. Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury. Pain. 2013;154:1680-90 pubmed publisher
Stuart S, Butler P, MunafÃ² M, Nutt D, Robinson E. A translational rodent assay of affective biases in depression and antidepressant therapy. Neuropsychopharmacology. 2013;38:1625-35 pubmed publisher
Ferreira S, Teixeira F, Garção P, Agostinho P, Ledent C, Cortes L, et al. Presynaptic CB(1) cannabinoid receptors control frontocortical serotonin and glutamate release--species differences. Neurochem Int. 2012;61:219-26 pubmed publisher
Hutchinson A, Deng J, Aryal D, Wetsel W, West A. Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. Neuropsychopharmacology. 2012;37:321-37 pubmed publisher
Kobayashi T, Washiyama K, Ikeda K. Inhibition of G-protein-activated inwardly rectifying K+ channels by the selective norepinephrine reuptake inhibitors atomoxetine and reboxetine. Neuropsychopharmacology. 2010;35:1560-9 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1982

SKU :

1982/10

product name :

Reboxetine mesylate

description :

Potent and selective noradrenalin uptake inhibitor; orally active

target :

Adrenergic Transporter Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

99%

storage :

Store at +4°C

observed molecular weight :

409.5

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Reboxetine mesylate is a potent and selective inhibitor of noradrenalin uptake (Ki values are 1.1, 129 and 10000 nM for rat NET, SERT and DAT respectively). Displays 1000-fold selectivity over -adrenoceptors, 5-HT, dopamine and muscarinic ACh receptors. Orally active antidepressant.

product keywords :

Potent selective noradrenalin noradrenaline reuptake inhibitors inhibits orally active Transporters NET Adrenergic adrenaline adrenalin Monoamine Neurotransmitter Adrenergic Transporters 1982,

extended description :

Potent and selective noradrenalin uptake inhibitor; orally active

chemical name text :

(2R*)-2-[(R*)-(2-Ethoxyphenoxy)phenylmethyl]morpholine mesylate

formula :

C19H23NO3.CH3SO3H

formula text :

C19H23NO3.CH3SO3H

cas num :

98769-84-7

USD :

264

USD 2025 :

272 USD

product details :

Potent and selective noradrenalin uptake inhibitor; orally active

more info or order :

Tocris Bioscience product webpage