SANT-1 | Tocris Bioscience 1974 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SANT-1

catalog :

1974

quantity :

10 mg (also 50 mg)

price :

197 USD

more info or order :

Tocris Bioscience product webpage

citations: 10

Reference
Yung T, Poon F, Liang M, Coquenlorge S, McGaugh E, Hui C, et al. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat Commun. 2019;10:4647 pubmed publisher
Sambathkumar R, Akkerman R, Dastidar S, Roelandt P, Kumar M, Bajaj M, et al. Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells. PLoS ONE. 2018;13:e0197046 pubmed publisher
Krentz N, Van Hoof D, Li Z, Watanabe A, Tang M, Nian C, et al. Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors. Dev Cell. 2017;41:129-142.e6 pubmed publisher
Fleury A, Hoch L, Martinez M, Faure H, Taddei M, Petricci E, et al. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci Rep. 2016;6:23479 pubmed publisher
Yuan X, Cao J, He X, Serra R, Qu J, Cao X, et al. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Nat Commun. 2016;7:11024 pubmed publisher
Nostro M, Sarangi F, Yang C, Holland A, Elefanty A, Stanley E, et al. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. Stem Cell Reports. 2015;4:591-604 pubmed publisher
Strating J, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, et al. Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein. Cell Rep. 2015;10:600-15 pubmed publisher
Hoch L, Faure H, Roudaut H, Schoenfelder A, Mann A, Girard N, et al. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB J. 2015;29:1817-29 pubmed publisher
Atwood S, Li M, Lee A, Tang J, Oro A. GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. Nature. 2013;494:484-8 pubmed publisher
Wang Y, Davidow L, Arvanites A, Blanchard J, Lam K, Xu K, et al. Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chem Biol. 2012;19:972-82 pubmed publisher

product information

brand :

Tocris

master code :

1974

SKU :

1974/10

product name :

SANT-1

description :

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

target :

Hedgehog Signaling Inhibitors

category :

Small Molecules

unit size :

10 mg (also 50 mg)

purity :

99%

observed molecular weight :

373.5

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Has been used in protocols to generate pancreatic cells from hPSCs.

catalog number base :

1974

product keywords :

inhibitors inhibits hedgehog Hh signaling antagonizes smoothened activity Signaling Signalling Smo Receptors antagonist Hedgehog Signaling Smoothened Receptors 1974,

extended description :

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

chemical name text :

N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine

formula :

C 23 H 27 N 5

formula text :

C23H27N5

cas num :

304909-07-7

2020 USD :

187

2021 USD :

197 USD

storage :

Desiccate at +4°C

more info or order :

Tocris Bioscience product webpage