SANT-1 | Tocris Bioscience 1974/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SANT-1

catalog :

1974/10

quantity :

10 mg (also 50 mg)

price :

245 USD

more info or order :

Tocris Bioscience product webpage

citations: 13

Reference
Triolo T, Matuschek J, Castro Gutierrez R, Shilleh A, Williams S, Hansen M, et al. Stem-Cell-Derived β-Like Cells with a Functional PTPN2 Knockout Display Increased Immunogenicity. Cells. 2022;11: pubmed publisher
Yung T, Poon F, Liang M, Coquenlorge S, McGaugh E, Hui C, et al. Sufu- and Spop-mediated downregulation of Hedgehog signaling promotes beta cell differentiation through organ-specific niche signals. Nat Commun. 2019;10:4647 pubmed publisher
Sambathkumar R, Akkerman R, Dastidar S, Roelandt P, Kumar M, Bajaj M, et al. Generation of hepatocyte- and endocrine pancreatic-like cells from human induced endodermal progenitor cells. PLoS ONE. 2018;13:e0197046 pubmed publisher
Cogger K, Sinha A, Sarangi F, McGaugh E, Saunders D, Dorrell C, et al. Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors. Nat Commun. 2017;8:331 pubmed publisher
Krentz N, Van Hoof D, Li Z, Watanabe A, Tang M, Nian C, et al. Phosphorylation of NEUROG3 Links Endocrine Differentiation to the Cell Cycle in Pancreatic Progenitors. Dev Cell. 2017;41:129-142.e6 pubmed publisher
Fleury A, Hoch L, Martinez M, Faure H, Taddei M, Petricci E, et al. Hedgehog associated to microparticles inhibits adipocyte differentiation via a non-canonical pathway. Sci Rep. 2016;6:23479 pubmed publisher
Yuan X, Cao J, He X, Serra R, Qu J, Cao X, et al. Ciliary IFT80 balances canonical versus non-canonical hedgehog signalling for osteoblast differentiation. Nat Commun. 2016;7:11024 pubmed publisher
Nostro M, Sarangi F, Yang C, Holland A, Elefanty A, Stanley E, et al. Efficient generation of NKX6-1+ pancreatic progenitors from multiple human pluripotent stem cell lines. Stem Cell Reports. 2015;4:591-604 pubmed publisher
Strating J, van der Linden L, Albulescu L, Bigay J, Arita M, Delang L, et al. Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein. Cell Rep. 2015;10:600-15 pubmed publisher
Hoch L, Faure H, Roudaut H, Schoenfelder A, Mann A, Girard N, et al. MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor. FASEB J. 2015;29:1817-29 pubmed publisher
Atwood S, Li M, Lee A, Tang J, Oro A. GLI activation by atypical protein kinase C ?/? regulates the growth of basal cell carcinomas. Nature. 2013;494:484-8 pubmed publisher
Wang Y, Davidow L, Arvanites A, Blanchard J, Lam K, Xu K, et al. Glucocorticoid compounds modify smoothened localization and hedgehog pathway activity. Chem Biol. 2012;19:972-82 pubmed publisher
Nefzger C, Su C, Fabb S, Hartley B, Beh S, Zeng W, et al. Lmx1a allows context-specific isolation of progenitors of GABAergic or dopaminergic neurons during neural differentiation of embryonic stem cells. Stem Cells. 2012;30:1349-61 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1974

SKU :

1974/10

product name :

SANT-1

description :

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

target :

Hedgehog Signaling Inhibitors

unit size :

10 mg (also 50 mg)

category :

Small Molecules

purity :

98%

storage :

Store at +4°C

observed molecular weight :

373.5

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells). Has been used in protocols to generate pancreatic cells from hPSCs. . For more information about how SANT-1 may be used, see our protocol: Generation of cells from hPSCs

product keywords :

inhibitors inhibits hedgehog Hh signaling antagonizes smoothened activity Signaling Signalling Smo Receptors antagonist Hedgehog Signaling Smoothened Receptors Organoids 1974,

extended description :

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

chemical name text :

N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4-(phenylmethyl)-1-piperazinamine

formula :

C23H27N5

formula text :

C23H27N5

cas num :

304909-07-7

USD :

235

USD 2025 :

245 USD

product details :

Inhibitor of hedgehog (Hh) signaling; antagonizes smoothened activity

more info or order :

Tocris Bioscience product webpage