SL 327 | Tocris Bioscience 1969/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SL 327

catalog :

1969/1

quantity :

1 mg (also 10 mg, 50 mg)

price :

143 USD

more info or order :

Tocris Bioscience product webpage

citations: 22

Reference
Zakharova I, Sokolova T, Bayunova L, Zorina I, Rychkova M, Shpakov A, et al. The Protective Effect of Insulin on Rat Cortical Neurons in Oxidative Stress and Its Dependence on the Modulation of Akt, GSK-3beta, ERK1/2, and AMPK Activities. Int J Mol Sci. 2019;20: pubmed publisher
Diaz A, Merino P, Manrique L, Ospina J, Cheng L, Wu F, et al. A Cross Talk between Neuronal Urokinase-type Plasminogen Activator (uPA) and Astrocytic uPA Receptor (uPAR) Promotes Astrocytic Activation and Synaptic Recovery in the Ischemic Brain. J Neurosci. 2017;37:10310-10322 pubmed publisher
Altmüller F, Pothula S, Annamneedi A, Nakhaei Rad S, Montenegro Venegas C, Pina Fernández E, et al. Aberrant neuronal activity-induced signaling and gene expression in a mouse model of RASopathy. PLoS Genet. 2017;13:e1006684 pubmed publisher
Oh J, Kim E, Choi Y, Nam T. Negative regulation of ERK1/2 by PI3K is required for the protective effects of Pyropia yezoensis peptide against perfluorooctane sulfonate-induced endoplasmic reticulum stress. Mol Med Rep. 2017;15:2583-2587 pubmed publisher
Rhim J, Luo X, Gao D, Xu X, Zhou T, Li F, et al. Cell type-dependent Erk-Akt pathway crosstalk regulates the proliferation of fetal neural progenitor cells. Sci Rep. 2016;6:26547 pubmed publisher
Liddell J, Lehtonen S, Duncan C, Keksa Goldsteine V, Levonen A, Goldsteins G, et al. Pyrrolidine dithiocarbamate activates the Nrf2 pathway in astrocytes. J Neuroinflammation. 2016;13:49 pubmed publisher
Urs N, Bido S, Peterson S, Daigle T, Bass C, Gainetdinov R, et al. Targeting Î²-arrestin2 in the treatment of L-DOPA-induced dyskinesia in Parkinson's disease. Proc Natl Acad Sci U S A. 2015;112:E2517-26 pubmed publisher
Seese R, Wang K, Yao Y, Lynch G, Gall C. Spaced training rescues memory and ERK1/2 signaling in fragile X syndrome model mice. Proc Natl Acad Sci U S A. 2014;111:16907-12 pubmed publisher
Lee Y, Ehninger D, Zhou M, Oh J, Kang M, Kwak C, et al. Mechanism and treatment for learning and memory deficits in mouse models of Noonan syndrome. Nat Neurosci. 2014;17:1736-43 pubmed publisher
Evron T, Peterson S, Urs N, Bai Y, Rochelle L, Caron M, et al. G Protein and Î²-arrestin signaling bias at the ghrelin receptor. J Biol Chem. 2014;289:33442-55 pubmed publisher
Kubota H, Nagao S, Obata K, Hirono M. mGluR1-mediated excitation of cerebellar GABAergic interneurons requires both G protein-dependent and Src-ERK1/2-dependent signaling pathways. PLoS ONE. 2014;9:e106316 pubmed publisher
Keasey M, Kang S, Lovins C, Hagg T. Inhibition of a novel specific neuroglial integrin signaling pathway increases STAT3-mediated CNTF expression. Cell Commun Signal. 2013;11:35 pubmed publisher
Freeman M, Kim J, Lisanti M, Di Vizio D. A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death. Cancer Biol Ther. 2011;12:966-77 pubmed publisher
Subramanian J, Morozov A. Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels. J Neurosci. 2011;31:4755-64 pubmed publisher
Osterweil E, Krueger D, Reinhold K, Bear M. Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. J Neurosci. 2010;30:15616-27 pubmed publisher
Urs N, Daigle T, Caron M. A dopamine D1 receptor-dependent ?-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice. Neuropsychopharmacology. 2011;36:551-8 pubmed publisher
Alter B, Zhao C, Karim F, Landreth G, Gereau R. Genetic targeting of ERK1 suggests a predominant role for ERK2 in murine pain models. J Neurosci. 2010;30:11537-47 pubmed publisher
Chen Roetling J, Li Z, Chen M, Awe O, Regan R. Heme oxygenase activity and hemoglobin neurotoxicity are attenuated by inhibitors of the MEK/ERK pathway. Neuropharmacology. 2009;56:922-8 pubmed publisher
Faccidomo S, Besheer J, Stanford P, Hodge C. Increased operant responding for ethanol in male C57BL/6J mice: specific regulation by the ERK1/2, but not JNK, MAP kinase pathway. Psychopharmacology (Berl). 2009;204:135-47 pubmed publisher
Beaulieu J, Sotnikova T, Gainetdinov R, Caron M. Paradoxical striatal cellular signaling responses to psychostimulants in hyperactive mice. J Biol Chem. 2006;281:32072-80 pubmed
García Fuster M, Miralles A, Garcia Sevilla J. Effects of opiate drugs on Fas-associated protein with death domain (FADD) and effector caspases in the rat brain: regulation by the ERK1/2 MAP kinase pathway. Neuropsychopharmacology. 2007;32:399-411 pubmed
Beaulieu J, Sotnikova T, Marion S, Lefkowitz R, Gainetdinov R, Caron M. An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. Cell. 2005;122:261-73 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1969

SKU :

1969/1

product name :

SL 327

description :

Selective inhibitor of MEK1 and MEK2; brain penetrant

target :

MEK Inhibitors

unit size :

1 mg (also 10 mg, 50 mg)

category :

Small Molecules

purity :

99%

storage :

Desiccate at +4°C

observed molecular weight :

335.35

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SL 327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 u M respectively); blocks hippocampal LTP in vitro . Brain penetrant in vivo , blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.

product keywords :

Selective inhibitors inhibits MEK1 MEK2 brain penetrant Mitogen-Activated Protein Kinase MEK Kinases SL327 MEK 1969,

extended description :

Selective inhibitor of MEK1 and MEK2; brain penetrant

chemical name text :

-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile

formula :

C16H12F3N3S

formula text :

C16H12F3N3S

cas num :

305350-87-2

USD :

137

USD 2025 :

143 USD

product details :

Selective inhibitor of MEK1 and MEK2; brain penetrant

more info or order :

Tocris Bioscience product webpage