Simvastatin | Tocris Bioscience 1965 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Simvastatin

catalog :

1965

quantity :

50 mg

price :

196 USD

more info or order :

Tocris Bioscience product webpage

citations: 4

Reference
Rojo Arreola L, Long T, Asarnow D, Suzuki B, Singh R, Caffrey C. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS ONE. 2014;9:e87594 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
Vainio P, Lehtinen L, Mirtti T, Hilvo M, Seppanen Laakso T, Virtanen J, et al. Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. Oncotarget. 2011;2:1176-90 pubmed
Seto S, Au A, Lam T, Chim S, Lee S, Wan S, et al. Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells. Br J Pharmacol. 2007;151:987-97 pubmed

product information

brand :

Tocris

master code :

1965

SKU :

1965/50

product name :

Simvastatin

description :

HMG-CoA reductase inhibitor

target :

HMG-CoA Reductase Inhibitors

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

418.57

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.

catalog number base :

1965

product keywords :

HMG-CoA reductase inhibitors inhibits Reductases ferroptosis hyperlipidemia hypolipemic statins HMG-CoA Reductase Ferroptosis 1965,

extended description :

HMG-CoA reductase inhibitor

chemical name text :

(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate

formula :

C 25 H 38 O 5

formula text :

C25H38O5

cas num :

79902-63-9

2020 USD :

188

2021 USD :

196 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage