Simvastatin | Tocris Bioscience 1965/50 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Simvastatin

catalog :

1965/50

quantity :

50 mg

price :

251 USD

more info or order :

Tocris Bioscience product webpage

citations: 5

Reference
Zhang K, Song W, Li D, Jin X. Apigenin in the regulation of cholesterol metabolism and protection of blood vessels. Exp Ther Med. 2017;13:1719-1724 pubmed publisher
Rojo Arreola L, Long T, Asarnow D, Suzuki B, Singh R, Caffrey C. Chemical and genetic validation of the statin drug target to treat the helminth disease, schistosomiasis. PLoS ONE. 2014;9:e87594 pubmed publisher
Seto S, Au A, Poon C, Zhang Q, Li R, Yeung J, et al. Acute simvastatin inhibits K ATP channels of porcine coronary artery myocytes. PLoS ONE. 2013;8:e66404 pubmed publisher
Vainio P, Lehtinen L, Mirtti T, Hilvo M, Seppanen Laakso T, Virtanen J, et al. Phospholipase PLA2G7, associated with aggressive prostate cancer, promotes prostate cancer cell migration and invasion and is inhibited by statins. Oncotarget. 2011;2:1176-90 pubmed
Seto S, Au A, Lam T, Chim S, Lee S, Wan S, et al. Modulation by simvastatin of iberiotoxin-sensitive, Ca2+-activated K+ channels of porcine coronary artery smooth muscle cells. Br J Pharmacol. 2007;151:987-97 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1965

SKU :

1965/50

product name :

Simvastatin

description :

HMG-CoA reductase inhibitor

target :

HMG-CoA Reductase Inhibitors

unit size :

50 mg

category :

Small Molecules

purity :

98%

storage :

Desiccate at -20°C

observed molecular weight :

418.57

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Simvastatin is a HMG-CoA reductase inhibitor; decreases levels of low density lipoprotein. Simvastatin is also an AMPK activator. Has multiple biological effects including bone formation stimulation, inhibition of smooth muscle cell proliferation and migration, induction of ferroptosis, inhibition of autophagy, and anticancer and anti-inflammatory activity. Inactive lactone prodrug of simvastatin hydroxy acid, naturally bioactivated in vivo following oral administration.Simvastatin acts synergistically with ABL allosteric inhibitors GNF 5 (Cat. No. 1965) to enhance apoptosis of metastatic lung cancer cells in mice.

product keywords :

HMG-CoA reductase inhibitors inhibits reductases ferroptosis hyperlipidemia hypolipemic statins AMPK autophagy HMG-CoA Reductase Ferroptosis AMPK Autophagy 1965,

extended description :

HMG-CoA reductase inhibitor

chemical name text :

(1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyly-2,2-dimethyl butanoate

formula :

C25H38O5

formula text :

C25H38O5

cas num :

79902-63-9

USD :

243

USD 2025 :

251 USD

product details :

HMG-CoA reductase inhibitor

more info or order :

Tocris Bioscience product webpage