Gossypol | Tocris Bioscience 1964 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Gossypol

catalog :

1964

quantity :

50 mg

price :

101 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Mani J, Vallo S, Rakel S, Antonietti P, Gessler F, Blaheta R, et al. Chemoresistance is associated with increased cytoprotective autophagy and diminished apoptosis in bladder cancer cells treated with the BH3 mimetic (-)-Gossypol (AT-101). BMC Cancer. 2015;15:224 pubmed publisher
Hsiao W, Tsai M, Jow G, Tien L, Lee Y. Involvement of Smac, p53, and caspase pathways in induction of apoptosis by gossypol in human retinoblastoma cells. Mol Vis. 2012;18:2033-42 pubmed
Pang X, Wu Y, Wu Y, Lu B, Chen J, Wang J, et al. (-)-Gossypol suppresses the growth of human prostate cancer xenografts via modulating VEGF signaling-mediated angiogenesis. Mol Cancer Ther. 2011;10:795-805 pubmed publisher

product information

brand :

Tocris

master code :

1964

SKU :

1964/50

product name :

Gossypol

description :

Proapoptotic; downregulates Bcl-2 and Bcl-XL

target :

Additional Bcl-2 Family Compounds

category :

Small Molecules

unit size :

50 mg

purity :

98%

observed molecular weight :

518.56

url print :

?utm_source=distributor&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

Lipophilic agent derived from cottonseed. Exhibits multiple biological effects including antifertility and anticancer activity. Proapoptotic; downregulates Bcl-2 and Bcl-XL. . R-enantiomer also available.

catalog number base :

1964

product keywords :

Pro-apoptotic downregulates Bcl-2 Bcl-XL Bax Mcl-1 Family Bcl-2 Family 1964,

extended description :

Proapoptotic; downregulates Bcl-2 and Bcl-XL

chemical name text :

1,1 ,6,6 ,7,7 -Hexahydroxy-3,3 -dimethyl-5,5 -bis(1-methylethyl)-[2,2 -binaphthalene]-8,8 -dicarboxaldehyde

formula :

C 30 H 30 O 8

formula text :

C30H30O8

cas num :

303-45-7

2020 USD :

101

2021 USD :

101 USD

storage :

Store at -20°C

more info or order :

Tocris Bioscience product webpage