product summary
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company name :
Tocris Bioscience
product type :
chemical
product name :
SB 408124
catalog :
1963/10
quantity :
10 mg
price :
261 USD
more info or order :
citations: 4
Reference
Suo L, Chang X, Zhao Y. The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells. Front Endocrinol (Lausanne). 2018;9:647 pubmed publisher
Morairty S, Revel F, Malherbe P, Moreau J, Valladao D, Wettstein J, et al. Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone. PLoS ONE. 2012;7:e39131 pubmed publisher
Xu T, Ward R, Pediani J, Milligan G. Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation. J Biol Chem. 2012;287:14937-49 pubmed publisher
Urbańska A, Sokołowska P, Woldan Tambor A, Biegańska K, Brix B, Jöhren O, et al. Orexins/hypocretins acting at Gi protein-coupled OX 2 receptors inhibit cyclic AMP synthesis in the primary neuronal cultures. J Mol Neurosci. 2012;46:10-7 pubmed publisher
product information
brand :
Tocris, a Bio-Techne brand
catalog number base :
1963
SKU :
1963/10
product name :
SB 408124
description :
Selective non-peptide OX1 antagonist
target :
OX1 Receptor Antagonists
unit size :
10 mg
category :
Small Molecules
purity :
98%
storage :
Store at RT
observed molecular weight :
356.37
url print :
?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules
details of functionality :
SB 408124 is a selective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). Blocks orexin-A induced grooming following oral administration in vivo .
product keywords :
Selective non-peptide OX1 antagonists Orexin1 Receptors SB408124 GlaxoSmithKline GSK OX1 Receptor 1963,
extended description :
Selective non-peptide OX1 antagonist
chemical name text :
N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N -[4-(dimethylamino)phenyl]urea
formula :
C19H18F2N4O
formula text :
C19H18F2N4O
cas num :
288150-92-5
USD :
258
USD 2025 :
261 USD
product details :
Selective non-peptide OX1 antagonist
more info or order :
company information
Tocris Bioscience
The Watkins Building
Atlantic Road
Avonmouth, Bristol
BS11 9QD
info@bio-techne.com
https://www.tocris.com
800-343-7475
headquarters: UK