SB 239063 | Tocris Bioscience 1962/10 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

SB 239063

catalog :

1962/10

quantity :

10 mg

price :

376 USD

more info or order :

Tocris Bioscience product webpage

citations: 11

Reference
Taoro Gonzalez L, Arenas Y, Cabrera Pastor A, Felipo V. Hyperammonemia alters membrane expression of GluA1 and GluA2 subunits of AMPA receptors in hippocampus by enhancing activation of the IL-1 receptor: underlying mechanisms. J Neuroinflammation. 2018;15:36 pubmed publisher
Uchiyama T, Okajima F, Mogi C, Tobo A, Tomono S, Sato K. Alamandine reduces leptin expression through the c-Src/p38 MAP kinase pathway in adipose tissue. PLoS ONE. 2017;12:e0178769 pubmed publisher
Yang Y, Li H, Li T, Luo H, Gu X, LÃ¼ N, et al. Delayed activation of spinal microglia contributes to the maintenance of bone cancer pain in female Wistar rats via P2X7 receptor and IL-18. J Neurosci. 2015;35:7950-63 pubmed publisher
Emery A, Eiden M, Eiden L. Separate cyclic AMP sensors for neuritogenesis, growth arrest, and survival of neuroendocrine cells. J Biol Chem. 2014;289:10126-39 pubmed publisher
Agusti A, Dziedzic J, Hernandez Rabaza V, Guilarte T, Felipo V. Rats with minimal hepatic encephalopathy due to portacaval shunt show differential increase of translocator protein (18 kDa) binding in different brain areas, which is not affected by chronic MAP-kinase p38 inhibition. Metab Brain Dis. 2014;29:955-63 pubmed publisher
Potapova I, Cohen I, Doronin S. Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells. PLoS ONE. 2013;8:e73929 pubmed publisher
Burke S, Goff M, Updegraff B, Lu D, Brown P, Minkin S, et al. Regulation of the CCL2 gene in pancreatic ?-cells by IL-1? and glucocorticoids: role of MKP-1. PLoS ONE. 2012;7:e46986 pubmed publisher
Hishida T, Nozaki Y, Nakachi Y, Mizuno Y, Iseki H, Katano M, et al. Sirt1, p53, and p38(MAPK) are crucial regulators of detrimental phenotypes of embryonic stem cells with Max expression ablation. Stem Cells. 2012;30:1634-44 pubmed publisher
Ferreira R, Santos T, Viegas M, Cortes L, Bernardino L, Vieira O, et al. Neuropeptide Y inhibits interleukin-1?-induced phagocytosis by microglial cells. J Neuroinflammation. 2011;8:169 pubmed publisher
He K, Aizenman E. ERK signaling leads to mitochondrial dysfunction in extracellular zinc-induced neurotoxicity. J Neurochem. 2010;114:452-61 pubmed publisher
Dobreva I, Waeber G, James R, Widmann C. Interleukin-8 secretion by fibroblasts induced by low density lipoproteins is p38 MAPK-dependent and leads to cell spreading and wound closure. J Biol Chem. 2006;281:199-205 pubmed

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1962

SKU :

1962/10

product name :

SB 239063

description :

Potent, selective p38 MAPK inhibitor; orally active

target :

p38 Inhibitors

unit size :

10 mg

category :

Small Molecules

purity :

98%

storage :

Desiccate at +4°C

observed molecular weight :

368.41

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=smallmolecules

details of functionality :

SB 239063 is a potent and selective p38 MAP kinase inhibitor (IC50 = 44 nM for p38 ). Displays 220-fold selectivity over ERK, JNK1 and other kinases; ~ 3-fold more selective than SB 203580 (Cat. Nos. 1202 and 1402). Reduces inflammatory cytokine production and is neuroprotective following oral administration in vivo .

product keywords :

Potent selective p38 MAP kinases inhibitors inhibits orally active MAPK Signaling Signalling Mitogen-Activated Protein SB239063 GlaxoSmithKline GSK p38 1962,

extended description :

Potent, selective p38 MAPK inhibitor; orally active

chemical name text :

trans-4-[4-(4-Fluorophenyl)-5-(2-methoxy-4-pyrimidinyl)-1H-imidazol-1-yl]cyclohexanol

formula :

C20H21FN4O2

formula text :

C20H21FN4O2

cas num :

193551-21-2

USD :

372

USD 2025 :

376 USD

product details :

Potent, selective p38 MAPK inhibitor; orally active

more info or order :

Tocris Bioscience product webpage