Gap 26 | Tocris Bioscience 1950/1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Gap 26

catalog :

1950/1

quantity :

1 mg

price :

344 USD

citations: 4

Reference
Almad A, Doreswamy A, Gross S, Richard J, Huo Y, Haughey N, et al. Connexin 43 in astrocytes contributes to motor neuron toxicity in amyotrophic lateral sclerosis. Glia. 2016;64:1154-69 pubmed publisher
Jones A, Gokhale P, Allison T, Sampson B, Athwal S, Grant S, et al. Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells. Sci Rep. 2015;5:11694 pubmed publisher
Thuringer D, Berthenet K, Cronier L, Jego G, Solary E, Garrido C. Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells. Oncotarget. 2015;6:10267-83 pubmed
Sakatani S, Seto Ohshima A, Shinohara Y, Yamamoto Y, Yamamoto H, Itohara S, et al. Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo. J Neurosci. 2008;28:10928-36 pubmed publisher

product information

brand :

Tocris, a Bio-Techne Brand

catalog number base :

1950

SKU :

1950/1

product name :

Gap 26

Description :

Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release

target :

Gap Channel Blockers

category :

Peptides

unit size :

1 mg

purity :

95%

observed molecular weight :

1550.79

url print :

?utm_source=labome&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Gap 26 is a peptide, corresponding to residues 63 - 75 of connexin 43, which is a gap junction blocker. Attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC50 = 28.4 M). Also inhibits IP3-induced ATP release, without inhibiting gap junctional coupling in endothelial cells.

extended description :

Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release

formula :

C 70 H 107 N 19 O 19 S

formula text :

C70H107N19O19S

cas num :

197250-15-0

USD :

344 USD

product details :

Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release

storage :

Store at -20°C