[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P | Tocris Bioscience 1946 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

catalog :

1946

quantity :

1 mg

price :

126 USD

more info or order :

Tocris Bioscience product webpage

citations: 3

Reference
Pastor Cavada E, Pardo L, Kandil D, Torres Fuentes C, Clarke S, Shaban H, et al. A Novel Non-Peptidic Agonist of the Ghrelin Receptor with Orexigenic Activity In vivo. Sci Rep. 2016;6:36456 pubmed publisher
Torres Fuentes C, Theeuwes W, McMullen M, McMullen A, Dinan T, Cryan J, et al. Devil's Claw to suppress appetite--ghrelin receptor modulation potential of a Harpagophytum procumbens root extract. PLoS ONE. 2014;9:e103118 pubmed publisher
Schellekens H, van Oeffelen W, Dinan T, Cryan J. Promiscuous dimerization of the growth hormone secretagogue receptor (GHS-R1a) attenuates ghrelin-mediated signaling. J Biol Chem. 2013;288:181-91 pubmed publisher

product information

brand :

Tocris

master code :

1946

SKU :

1946/1

product name :

[D-Arg1,D-Phe5,D-Trp7,9,Leu11]-Substance P

description :

Potent ghrelin receptor inverse agonist; Antagonist at other neuropeptide receptors

target :

Ghrelin Receptor Inverse Agonists

category :

Peptides

unit size :

1 mg

observed molecular weight :

1516.85

url print :

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details of functionality :

Broad spectrum neuropeptide inverse agonist and antagonist. Potent full inverse agonist for the ghrelin receptor (EC50 = 5.2 nM); diminishes constitutive ghrelin receptor signaling. Also antagonist at tachykinin, bradykinin, CCK and bombesin receptors. Induces apoptosis and inhibits cancer cell growth in vitro .

catalog number base :

1946

product keywords :

Substance P broad spectrum neuropeptide receptor antagonists inverse agonists Potent ghrelin Tachykinin Neurokinin Receptors GHS-R1a Growth Hormone Secretagog Receptor 1a Ghrelin [D-Arg1D-Phe5D-Trp79Leu11]-SubstanceP neuropeptides Ghrelin Receptors Other Tachykinin 1946,

extended description :

Potent ghrelin receptor inverse agonist; Antagonist at other neuropeptide receptors

formula :

C 79 H 109 N 19 O 12

formula text :

C79H109N19O12

cas num :

96736-12-8

2020 USD :

139

2021 USD :

126 USD

storage :

Desiccate at -20°C

more info or order :

Tocris Bioscience product webpage