Exendin-4 | Tocris Bioscience 1933/1 product information

product summary

company name :

Tocris Bioscience

product type :

chemical

product name :

Exendin-4

catalog :

1933/1

quantity :

1 mg

price :

508 USD

more info or order :

Tocris Bioscience product webpage

citations: 13

Reference
Jesinkey S, Madiraju A, Alves T, Yarborough O, Cardone R, Zhao X, et al. Mitochondrial GTP Links Nutrient Sensing to β Cell Health, Mitochondrial Morphology, and Insulin Secretion Independent of OxPhos. Cell Rep. 2019;28:759-772.e10 pubmed publisher
Vallöf D, Vestlund J, Jerlhag E. Glucagon-like peptide-1 receptors within the nucleus of the solitary tract regulate alcohol-mediated behaviors in rodents. Neuropharmacology. 2019;149:124-132 pubmed publisher
Lutter M, Bahl E, Hannah C, Hofammann D, Acevedo S, Cui H, et al. Novel and ultra-rare damaging variants in neuropeptide signaling are associated with disordered eating behaviors. PLoS ONE. 2017;12:e0181556 pubmed publisher
Watson L, Tsai L. Molecular biology: Local metabolites linked to memory. Nature. 2017;546:361-362 pubmed publisher
Tuesta L, Chen Z, Duncan A, Fowler C, Ishikawa M, Lee B, et al. GLP-1 acts on habenular avoidance circuits to control nicotine intake. Nat Neurosci. 2017;20:708-716 pubmed publisher
Burmeister M, Ayala J, Smouse H, Landivar Rocha A, Brown J, Drucker D, et al. The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice. Diabetes. 2017;66:372-384 pubmed publisher
Al Madhoun A, Ali H, AlKandari S, Atizado V, Akhter N, Al Mulla F, et al. Defined three-dimensional culture conditions mediate efficient induction of definitive endoderm lineage from human umbilical cord Wharton's jelly mesenchymal stem cells. Stem Cell Res Ther. 2016;7:165 pubmed
Saxena P, Heng B, Bai P, Folcher M, Zulewski H, Fussenegger M. A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells. Nat Commun. 2016;7:11247 pubmed publisher
Ho J, Anekonda V, Thompson B, Zhu M, Curry R, Hwang B, et al. Hindbrain oxytocin receptors contribute to the effects of circulating oxytocin on food intake in male rats. Endocrinology. 2014;155:2845-57 pubmed publisher
Lee J, Sugiyama T, Liu Y, Wang J, Gu X, Lei J, et al. Expansion and conversion of human pancreatic ductal cells into insulin-secreting endocrine cells. elife. 2013;2:e00940 pubmed publisher
Suissa Y, Magenheim J, Stolovich Rain M, Hija A, Collombat P, Mansouri A, et al. Gastrin: a distinct fate of neurogenin3 positive progenitor cells in the embryonic pancreas. PLoS ONE. 2013;8:e70397 pubmed publisher
Wang D, Luo P, Wang Y, Li W, Wang C, Sun D, et al. Glucagon-like peptide-1 protects against cardiac microvascular injury in diabetes via a cAMP/PKA/Rho-dependent mechanism. Diabetes. 2013;62:1697-708 pubmed publisher
Pritchett C, Hajnal A. Glucagon-like peptide-1 regulation of carbohydrate intake is differentially affected by obesogenic diets. Obesity (Silver Spring). 2012;20:313-7 pubmed publisher

product information

brand :

Tocris, a Bio-Techne brand

catalog number base :

1933

SKU :

1933/1

product name :

Exendin-4

description :

Potent GLP-1 receptor agonist

target :

Glucagon-Like Peptide 1 Receptor Agonists

unit size :

1 mg

category :

Peptides

purity :

95%

storage :

Store at -20°C

observed molecular weight :

4186.61

url print :

?utm_source=biocompare&utm_medium=referral&utm_campaign=product&utm_term=peptides

details of functionality :

Exendin-4 is a high affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM); originally isolated from Heloderma suspectum venom. Exendin-4 potently induces cAMP formation without stimulating amylase release in pancreatic acini. Potentiates glucose-induced insulin secretion in isolated rat islets. Exendin-4 protects against glutamate-induced neurotoxicity, and in a mouse model of metabolic imblance it reduces neuroinflammation and enhances long-term-potentiation.

product keywords :

Potent GLP-1 receptor agonists Receptors Glucagon-Like Peptide 1 AC2993 Ex4 exenatide neuroprotective neuroinflammation neurotoxicity LTP Exenatide AC 2993 Glucagon-Like Peptide 1 Receptors 1933,

extended description :

Potent GLP-1 receptor agonist

formula :

C184H282N50O60S

formula text :

C184H282N50O60S

cas num :

141758-74-9

USD :

487

USD 2025 :

508 USD

product details :

Potent GLP-1 receptor agonist

alt names :

Exenatide,AC 2993

more info or order :

Tocris Bioscience product webpage